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Zebrafish Models of Congenital Myopathy
(2015-08-31)
The congenital myopathies are a diverse group of inherited neuromuscular disorders that manifest as skeletal muscle weakness at birth or in infancy, and are classically defined by the predominant morphological features ...
The Programming and Assembly of a Transcriptional Silencing Complex
(2015-09-23)
Argonautes and their small RNA guides form an ancient partnership with diverse roles in controlling gene expression and preserving genome stability. In the fission yeast Schizosaccharomyces pombe, the Argonaute Ago1 acts ...
Biology of Type 2 Phosphatidylinositol-5-Phosphate 4-Kinase
(2015-09-22)
Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes ...
Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
Transcriptional Controls Over Specification of Neocortical Projection Neuron Subtype and Area Identity
(2015-08-04)
The complex and sophisticated neocortical circuits that mediate higher-order brain functions are assembled from an extraordinary variety of neuronal subtypes, each with distinct morphologies, output connectivity, and ...
Postnatal Genome Editing With CRISPR
(2016-05-18)
Targeted genome editing holds tremendous promise for permanent correction of many genetic diseases. The recently developed CRISPR/Cas9 genome-editing tool exhibits facile programmability and robust gene-editing efficiency, ...
Investigating Mechanisms of DNA Double Strand Break Joining of Switch Regions During IgH Class Switch Recombination
(2016-05-19)
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional ...
Gain-of-Function Genetic Screens Using Barcoded Libraries of Human Open Reading Frames Identify Regulators of Proliferation and Cancer Drivers
(2015-05-17)
The identification of genetic events that cause tumorigenesis is a key goal of cancer research. While recent sequencing efforts have provided unprecedented illumination of cancer genomes, the inherent genomic instability ...
In Vivo and in Vitro Characterization of the Tumor Suppressive Function of INPP4B
(2015-05-16)
The phosphatases PTEN and INPP4B are frequently deregulated in human cancer and have been proposed to act as tumor suppressor genes by coordinately antagonizing PI3K/AKT signaling. While the function of PTEN has been ...
Discovery and Functional Interpretation of Genetic Risk in Autoimmune Diseases
(2015-05-08)
Autoimmune diseases are chronic and debilitating conditions arising from abnormal immune responses directed against normal body tissues; they collectively affect the lives of 5-10% of the world population. These diseases ...