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Formation of a Termination-Resistant RNA Polymerase Complex: Studies on the Phage 82 Q Protein
(2015-07-22)
Due to their early discovery, relative simplicity, and well-defined function, the Q antiterminator proteins of bacteriophage lambda and related lambdoid phages serve as a model for understanding how the elongation and ...
Allosteric Integrase Inhibitors Reveal a Role for Integrase During HIV-1 Maturation
(2015-09-20)
Integration of the DNA copy of the HIV-1 genome is an essential step for virus replication and is mediated by a homotetrameric complex of the viral protein integrase (IN) in association with the ends of linear viral DNA ...
Rabies Glycoprotein-Mediated Uptake Into Epithelial Cells and Compartmentalized Primary Neuronal Culture
(2015-09-29)
Rabies virus (RABV) subverts host neuronal circuitry to gain access to the brain where it causes generally incurable, lethal encephalitis. The single glycoprotein (G) dictates two defining steps for infection and neuroinvasion: ...
Role of the secretome in manganese and carbon oxidation by filamentous ascomycete fungi
(2015-09-19)
Fungi are the primary decomposers of recalcitrant plant and animal material in terrestrial environments, thereby serving as important drivers of global carbon cycling and climate dynamics and as mediators in renewable ...
Mycobacterial Metabolic Syndrome: Triglyceride Accumulation Decreases Growth Rate and Virulence of Mycobacterium Tuberculosis
(2015-01-23)
Mycobacterium tuberculosis (Mtb) mutants lacking the operon Rv1411c-1410c encoding a lipoprotein, Rv1411c (LprG) and a putative transporter, Rv1410c (Rv1410) are dramatically attenuated for growth in mice. Previous work ...
Differential fluorescence-based genetic screens to identify novel Listeria monocytogenes virulence determinants
(2015-01-23)
Listeria monocytogenes is a Gram-positive, facultative intracellular pathogen that causes gastroenteritis, which in the young, the elderly, and the immunocompromised can progress to severe invasive disease with high ...
Complexity in Mutualisms: Indirect Interactions With Multiple Parties
(2015-09-23)
Ant-plants provide ants with rewards such as housing and food in exchange for protection from herbivores. These protection mutualisms are complex webs of both direct interactions, such as ants feeding on host plant extrafloral ...
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(2016-05-14)
Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ...
Abiotic Influences on Free-Living Microbial Communities in Hydrothermal Vent Ecosystems
(2016-05-18)
Hydrothermal vent ecosystems are defined by steep thermal and chemical gradients. Chemosynthetic microorganisms are the primary producers in these systems, utilizing the available chemical energy to support substantial ...
Plasmodium's Crossroads: Deciphering the Molecular Pathway That Leads to Malaria Transmission
(2015-05-13)
Plasmodium falciparum is the causative agent of the most severe form of malaria. Transmission from humans to mosquito vectors is an essential step in this eukaryotic parasite‘s life cycle and in the spread of malaria ...