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Establishment and Control of Behavioral Bias in Drosophila Melanogaster
(2018-05-13)
Typically, variability observed across populations of animals is considered to be experimental noise. However, it is clear that individuals display considerable idiosyncrasies in behavior that are stable over both short ...
Regulation of Transcytosis Underlies Blood-Brain Barrier Permeability
(2018-01-08)
The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. A single layer of continuous endothelial cells lining the walls of central nervous system (CNS) ...
Value Representations in Visual Association Cortex
(2018-09-16)
The needs of the body can direct neural processing towards motivationally-relevant sensory stimuli. For example, humans attend more to food cues during hungry versus sated states. Human neuroimaging studies consistently ...
Hidden State Inference in the Midbrain Dopamine System
(2018-05-11)
Midbrain dopamine neurons signal reward prediction error (RPE), or actual minus expected reward. The temporal difference (TD) learning model has been a cornerstone in understanding how dopamine RPEs could drive associative ...
New Roles for Attention and Memory in the Cocktail Party Problem
(2018-01-22)
Listening to one sound source among many (‘the cocktail party problem’) is particularly difficult when competing sources are similar and change over time. Such sources may not have consistent features (e.g., high vs. low ...
α-Synuclein Induces Mitochondrial Dysfunction Through Spectrin and the Actin Cytoskeleton
(2018-09-16)
Abnormal accumulation of the cytoplasmic protein α-synuclein in vulnerable neurons and glial is a pathological hallmark of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, collectively termed ...
Dendrite Patterning as a Model for Self-Organizing Systems
(2018-01-05)
Biological systems self-organize into complex well-ordered structures and can evolve new patterns when perturbed. To identify principles underlying self-organization, I turned to the model organism C. elegans for its ...
The Mesoscale Functional Organization of Mouse Cortex During Behavior
(2018-07-09)
Visually-guided navigation engages a network of cortical areas to process sensory information and plan movements, including visual, parietal, and retrosplenial regions. These regions have been mapped based on anatomy and ...
All-Optical Neurophysiology in the 1-Photon Regime
(2018-05-13)
Simultaneous optical recording and optical stimulation of neuronal activity could enable faster and more comprehensive investigation of neuronal function but is hampered by underdeveloped tools. Pairs of molecular transducers ...
A Computational Approach to Analysis and Control\\of the Mammalian Circadian Oscillator
(2018-05-11)
Circadian rhythms, endogenous, entrainable, near-24 h oscillations in metabolism, are a nearly ubiquitous feature of life on Earth. Circadian rhythms function as a feedforward biological control system that reorganizes ...