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The Molecular Determinants of Cranial Skeletal Development and Evolution
(2015-10-01)
The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...
Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia
(2015-01-15)
Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...
Mechanisms of Stem Cell Maintenance and Cell Differentiation in the Intestinal Epithelium
(2015-01-23)
Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This ...
Co-opting Intracellular Proteins for Cell-Specific Gene Manipulation
(2015-01-22)
Studies of complex multicellular organisms would benefit from the ability to selectively manipulate the activities of any cell type of interest. Our ability to achieve this is currently limited by technology and available ...
Investigating Mechanisms of DNA Double Strand Break Joining of Switch Regions During IgH Class Switch Recombination
(2016-05-19)
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional ...
Transcriptional Control of Maternal-Fetal Immune Tolerance
(2016-05-18)
Human leukocyte antigens (HLA) are important determinants of self-nonself immune recognition. HLA-G, uniquely expressed in the placenta, is believed to be key to fetus-induced immune tolerance during pregnancy. The ...
Diverse Approaches to Developing Combination Therapies for NF1-Mutant Cancers
(2015-05-13)
The NF1 tumor suppressor is lost or mutated in a variety of sporadic cancers, as well as in the hereditary cancer predisposition syndrome neurofibromatosis type 1 (NF1). NF1 patients have an 8–13% risk of developing a ...
Biosensing for Multiplexed Genome Engineering: Applications in Renewable Chemical Production
(2015-05-15)
Engineered biological systems are increasingly used to produce fuels, pharmaceuticals and industrial chemicals. While transforming cells into renewable chemical factories presents an enormous opportunity, development ...
Balancing transcriptional activity in Drosophila through protein-protein interactions on chromatin
(2016-05-09)
Chromatin plays a vital role in the implementation of gene expression programs. Several disparate groups of regulatory proteins alter chromatin state through post-translational modification of histone proteins, nucleosome ...