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Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
In Vivo and in Vitro Characterization of the Tumor Suppressive Function of INPP4B
(2015-05-16)
The phosphatases PTEN and INPP4B are frequently deregulated in human cancer and have been proposed to act as tumor suppressor genes by coordinately antagonizing PI3K/AKT signaling. While the function of PTEN has been ...
The Metabolic Role of the Hippo Pathway in Liver Development and Cancer
(2015-05-12)
Hepatocellular carcinoma (HCC) is a global health problem with poor prognosis and limited therapeutic options. While the clinical risk factors for HCC are well described, the precise molecular and metabolic mechanisms ...
Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation
(2016-03-30)
A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
Organization of Postsynaptic Assembly by Filamin at the Drosophila Neuromuscular Junction
(2016-05-16)
Proper postsynaptic assembly is a fundamental requirement for circuit function, yet our understanding of its molecular mechanism is incomplete. The Drosophila neuromuscular junction is a powerful system for genetically ...
Homology and Heterology Effects in Drosophila: Cohesin and Condensin as Chromosome Choreographers
(2016-05-02)
The organization of interphase nuclei has numerous consequences for gene expression and genome stability in eukaryotes. Here, we present studies of chromosome organization in Drosophila melanogaster over the course of the ...
Estrogen Signaling in Breast Tumorigenesis
(2016-09-09)
The estrogen receptor (ER) is expressed in approximately 70% of sporadic breast cancers and is believed to activate genes driving tumorigenesis and initial cell proliferation. Therapeutic targeting of the ER signaling ...
A genetic dissection of the interactions between the CbtA toxin of Escherichia coli and the bacterial cytoskeleton
(2016-09-15)
Prokaryotic chromosomal toxin-antitoxin (TA) systems, consisting of a stable toxin and a labile, cotranscribed antitoxin, have been shown to target a number of essential processes in bacteria. The Escherichia coli genome ...
Interrogation of the RP-MDM2-P53 Axis in Human Ribosomopathies
(2015-05-15)
Ribosomopathies such as Diamond-Blackfan anemia (DBA) and 5q- syndrome are human diseases characterized by heterozygous loss or mutation of ribosome-associated genes. Hallmarks of these diseases include a macrocytic anemia ...
Developments in Human Pluripotent Stem Cell Genome Engineering and in Situ Sequencing Technologies
(2015-05-19)
Technology is a key driving force in the advancement of scientific discoveries. While DNA sequencing uncovered the blueprint of life encoded in the human genome, functional roles of sequence variants remain largely unknown. ...