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The Discovery and Characterization of Endosomal Escape Enhancing Compounds to Improve Protein Delivery Efficacy
(2015-07-23)
The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ...
A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil From [18F]Fluoride for Human PET Imaging
(2015-07-20)
5-Fluorouracil is a broad-spectrum chemotherapeutic for cancer treatment. [18F]5-Fluorouracil, which contains the radioactive isotope fluorine-18, is a tracer for positron emission tomography (PET) imaging and has been ...
Multifunctional Three-Dimensional Nanoelectronic Networks for Smart Materials and Cyborg Tissues
(2015-09-28)
Nanomaterials provide unique opportunities at the interface between nanoelectronics and biology. “Bottom-up” synthesized nanowire(NW) with defined functionality can be assembled and enabled into three-dimensional(3D) ...
Activation of Electron-Deficient Quinones Through Hydrogen-Bond-Donor-Coupled Electron Transfer
(2015-09-23)
Quinones are organic oxidants that play important roles in biological contexts and find wide application in organic synthesis. They are known to be activated toward electron transfer through hydrogen bonding, which has ...
Advances in Crystal Growth and Assembly for Imparting Novel Photonic Properties to Semiconductor Nanowires
(2015-08-17)
Semiconductor nanowires comprise a versatile materials platform with which to characterize the properties of nanomaterials. The vast range of structural and compositional diversity of nanowires has also enabled their use ...
Polynuclear Cobalt Complexes as Models of a Cobalt Water Oxidation Catalyst
(2015-08-18)
The electrochemical oxidation of Co2+ ions in the presence of a buffering species such as phosphate (Pi), methyl phosphonate (MePi), and borate (Bi) leads to the formation of amorphous cobalt oxide thin films that are ...
On the Biological Activity of the Natural Product (+)-Avrainvillamide
(2015-05-07)
Nucleophosmin (NPM1) is a multifunctional phosphoprotein localized predominantly within the nucleoli of eukaryotic cells. Mutations within its C-terminal domain are frequently observed in patients with acute myeloid leukemia ...
Novel nanowire structures and devices for nanoelectronic bioprobes
(2015-04-29)
Semiconductor nanowire materials and devices provide unique opportunities in the frontier between nanoelectronics and biology. The bottom-up paradigm enables flexible synthesis and patterning of nanoscale building blocks ...
I. Synthesis of C4-Modified Tetracyclines II. Aldolizations of Pseudoephenamine Glycinamide and Applications Toward the Synthesis of Monocyclic β-Lactam Antibiotics
(2015-05-14)
Part one of this thesis describes the production of C4-modified tetracycline derivatives. Our synthetic strategy originally targeted SF2575, a C4-oxygenated tetracycline analog with antiproliferative properties, but was ...
The Electrocatalytic Evolution of Oxygen and Hydrogen by Cobalt and Nickel Compounds
(2015-05-21)
In order to meet the ever-increasing demand for energy, a worldwide transition away from fossil fuels to renewable solar–fuels is required. However, the intermittency of local insolation mandates a cost-effective and ...