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Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
(2018-04-19)
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...
Mechanistic Studies of First-Row Metal-Mediated and -Catalyzed Reactions
(2018-04-10)
First-row transition metals find growing applications in organic transformations due to their abundance and low cost. In addition, the difference in redox states of first-row metals to those of second or third row metals ...
A Platform for the Discovery of New Lincosamide Antibiotics
(2018-05-10)
This dissertation presents a flexible synthetic approach to the lincosamide antibiotics, developed with the aim of rejuvenating an underexploited class to combat multidrug-resistant bacterial pathogens. The only clinically ...
Development of Small Molecule Kinase Degraders as Chemical Biology Probes and Cancer Therapies
(2018-09-20)
Advances in chemical biology provide immense benefits to human health through the discovery of new medicines and new scientific tools to study disease. I have contributed to the advancement of this field by developing a ...
Nonhydrolyzable Ribonucleotide Phosphoroimidazolide Analogues for Mechanistic Studies of Nonenzymatic RNA Replication
(2018-04-17)
Efficient and faithful replication of genomic information is perhaps one of the most important hallmarks of cellular life. At some early point, such processes must have occurred in the absence of elaborate nucleic acid or ...
Evolution of Diversely Functionalized Nucleic Acid Polymers
(2018-04-19)
Darwinian evolution gave rise to biopolymers with a myriad of folded structures and functions, as well as all the diverse life forms on earth that are supported by those molecules. Amazingly, the essence of molecular ...
The Development of a Cell-Based Screen for Discovering Lipopolysaccharide Biogenesis Inhibitors
(2018-09-16)
Gram-negative bacteria are more difficult to kill than Gram-positive bacteria due to the presence of an outer membrane that prevents many antibiotics from reaching their cellular targets. The outer membrane is an asymmetric ...
Patterning Metal Oxides Using Electrochemical Methods and Exploring the Dynamics of Water-Splitting Catalysts
(2018-05-11)
Artificial photosynthesis is the electrochemical decomposition of water into oxygen and hydrogen driven by solar energy, allowing for the storage of solar energy in chemical bonds. Integrated photoelectrochemical cells ...
Small Molecule Reactivity and Electron Transfer Studies of Multinuclear Cobalt Complexes
(2018-02-23)
The activation of small molecules (N2, O2, H2O, H2, CO2) is central to renewable energy conversion and storage technologies such as solar cells, fuel cells, and solar to liquid fuels conversions. These transformations ...