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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(2016-05-14)
Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ...
Abiotic Influences on Free-Living Microbial Communities in Hydrothermal Vent Ecosystems
(2016-05-18)
Hydrothermal vent ecosystems are defined by steep thermal and chemical gradients. Chemosynthetic microorganisms are the primary producers in these systems, utilizing the available chemical energy to support substantial ...
Selection for Antibiotic Production
(2016-05-18)
Antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species. However, despite their genetic potential, natural isolates often make only small amounts of antibiotics and laboratory ...
Microbiome-Targeted Interventions for Colitis-Associated Bacteria
(2016-05-06)
Complex interactions between mammalian hosts and their gut microbes have evolved over many millennia and have established a sophisticated communication system that is essential for symbiosis and mutualism. Perturbations ...
Post-Transcriptional Control of Multicellularity in Bacillus subtilis
(2016-05-13)
Bacteria are capable of sensing changes in their environment and responding to those changes by altering patterns of gene expression. There are many mechanisms by which bacteria can sense internal and external signals. The ...
Mechanisms Controlling the Cell Envelope Remodeling Activities of the Escherichia Coli Cytokinetic Ring
(2016-05-13)
In Escherichia coli, cytokinesis requires the constriction of all the cell envelope layers: the inner membrane, the peptidoglycan (PG) cell wall and the outer membrane (OM). Such dramatic cell envelope remodeling requires ...
Mode and Fidelity of Bacterial Symbiont Transmission and Its Impact on Symbiont Genome Evolution
(2016-05-18)
Mutualistic symbioses have enabled the colonization of novel habitats and niches in a large array of eukaryotic and bacterial taxa. Reliable mechanisms of symbiont transmission between host generations are necessary to ...
Competition and Coexistence in Yeast Experimental Evolution
(2016-05-19)
Natural selection gives rise to biodiversity by purging the less-fit among variants that are too similar (a principle known as character displacement), but to predict how fit or different an organism needs to be to survive ...
The Genetics of Life History Traits in the Fungus Neurospora crassa
(2016-05-13)
The study of life histories is fundamental to understanding why some organisms live for a very short time while others live for a long time, why some produce thousands of offspring while others produce one, or why some ...
Genome evolution in structured systems
(2016-05-14)
The evolution of a genome is shaped by spatial interactions at multiple scales. At the angstrom level, structural constraints on both RNA molecules and proteins contribute to the evolution of a gene sequence. Such optimized ...