Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...

Despite the dramatic clinical success of cancer immunotherapy with PD-1 checkpoint blockade, most patients do not experience sustained clinical benefit from treatment, suggesting that additional therapeutic strategies are ...

Steering is a fundamental component of orienting behavior. It can be guided by external sensory cues, internal drives, and goal directions stored in working memory. Steering behavior provides an opportunity to study how ...

The gastrointestinal tract, home to a vast number of bacteria, requires finely-tuned regulatory and effector immune mechanisms to maintain homeostasis and tolerance. In a large-scale screen, we studied the impacts of single ...

The control of respiration and body temperature involves neural circuits within the brainstem modulated by the neurotransmitter serotonin (5HT), though it is unclear precisely which serotonergic neurons are critical to ...

Efficient skeletal muscle regeneration requires the accumulation of Foxp3+CD4+ regulatory T (Treg) cells. Muscle Tregs have a transcriptome and T cell receptor repertoire distinct from Tregs found in other tissues. The ...

Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast tumors are classified based on the ...

The complex and sophisticated neocortical circuits that mediate higher-order brain functions are assembled from an extraordinary variety of neuronal subtypes, each with distinct morphologies, output connectivity, and ...

Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes ...

Mutations in several genes that encode centrosomal proteins dramatically decrease the size of the human brain, which is the largest in the primate lineage, but how the proteins encoded by these microcephaly (‘small brain’) ...