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On Clocks and Tuners: Cyanobacterial Strategies to Thrive in a Dynamic Environment
(2018-01-05)
The cycle of day and night is among the most recurrent and predictable environmental changes. In order to thrive, organisms across all domains of life evolved regulatory strategies to respond to diurnal fluctuations in ...
Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis
(2018-04-10)
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
Integrating Regulatory Information in Eukaryotic Transcription
(2018-08-17)
Transcriptional regulation is a key determinant of cell differentiation during development. Changes in where and when a gene is expressed can lead to phenotypic variation among individuals, and ultimately to phenotypic ...
Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
(2018-04-19)
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...
High-Throughput Genetic Analysis of Single Cells Using Microfluidically Generated Hydrogels
(2018-01-22)
Typical metagenomic datasets characterize populations as a whole by sequencing all the DNA fragments present in a sample, and are therefore unable to identify different genes as having originated from the same cell or ...
Genetic Basis of Natural Variation in Cellular Decision Making in Wild Yeasts
(2018-05-15)
In nature, microbes often need to decide which of many potential nutrients to consume. This decision-making process is complex, involving both intracellular constraints and the organism’s perception of the environment. ...
Glycomic regulation of human B cells
(2018-09-16)
All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...
Intergenerational Transmission of Non-Germline RNAs in Caenorhabditis Elegans
(2018-05-13)
In the model organism Caenorhabditis elegans, double-stranded RNA (dsRNA) capable of silencing genes can be introduced anywhere in the animal and will subsequently travel throughout the body and enter most cells, including ...
Probing Nanopore - DNA Interactions With MspA
(2018-05-11)
Nanopores can be used as extremely sensitive instruments to directly measure properties of individual molecules. Progress in the nanopore field has been motivated largely by a desire to sequence DNA quickly and accurately. ...
Msp1 Protects Organelles Through Quality Control of Excess Membrane Proteins
(2018-01-16)
Quality control (QC) of membrane proteins is a critical but ill-understood process where undesirable proteins are sequestered or eliminated to protect cellular homeostasis. A recently described membrane protein QC pathway ...