The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ...

Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...

The capability to transmit information from generation to generation is an essential feature of life. In all terrestrial life, DNA and RNA contain information in the form of a sequence of monomers and are copied in every ...

Macrocyclic natural products occupy a special niche in the small molecule chemical space. Compared with other classes of small molecules, their larger size and conformational flexibility confer a higher propensity to ...

The chromosomal passenger complex (CPC) is a conserved protein complex regulating cell division. Although the kinase subunit, Aurora B (AURKB), self-activates through autophosphorylation, it remains unclear how this happens ...

Efficient and faithful replication of genomic information is perhaps one of the most important hallmarks of cellular life. At some early point, such processes must have occurred in the absence of elaborate nucleic acid or ...

Nature constructs structurally diverse, bioactive molecules using enzymes. Many enzymes catalyze synthetically challenging reactions under mild, physiological conditions. Consequently, they have long been a source of ...

The consortium of microorganisms inhabiting the human gastrointestinal tract, our gut microbiota, has an extensive set of metabolic capabilities that directly influence human health. Over the past decade, DNA sequencing ...

Epigenetic mechanisms regulate gene expression and mediate interactions between genetic factors and environmental exposures. The enzymes responsible for epigenetic regulation may thus be important therapeutic targets for ...

Life on earth may have first appeared in the form of a protocell capable of metabolism and containing a self-replicating informational polymer. This polymer was likely to have been RNA due to its ability to serve both as ...