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Understanding Generalization, Credit Assignment and the Regulation of Learning Rate in Human Motor Learning
(2013-02-20)
Understanding the neural processes underlying motor learning in humans is important to facilitate the acquisition of new motor skills and to aid the relearning of skills lost after neurologic injury. Although it is known ...
Re-Engineering the Tumor Microenvironment to Enhance Drug Delivery
(2013-02-22)
Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by non-uniform drug delivery via blood vessels, inhomogeneous drug transport ...
Robotic Catheters for Beating Heart Surgery
(2012-12-12)
Compliant and flexible cardiac catheters provide direct access to the inside of the heart via the vascular system without requiring clinicians to stop the heart or open the chest. However, the fast motion of the intracardiac ...
From Womb to Doom: Mechanical Regulation of Cardiac Tissue Assembly in Morphogenesis and Pathogenesis
(2013-02-14)
The assembly, form, and function of the heart is regulated by complex mechanical signals originating from intrinsic and extrinsic sources, such as the cytoskeleton and the extracellular matrix. During development, mechanical ...
Bioinspired, Dynamic, Structured Surfaces for Biofilm Prevention
(2012-11-14)
Bacteria primarily exist in robust, surface-associated communities known as biofilms, ubiquitous in both natural and anthropogenic environments. Mature biofilms resist a wide range of biocidal treatments and pose persistent ...
Nitric Oxide and Postconditioning: Cardioprotective Methods for Acute Care of Ischemia Reperfusion Injury
(2012-11-13)
Timely coronary artery reperfusion is essential to prevent myocyte death following myocardial infarction. The act of restoring blood flow however, paradoxically reduces the beneficial effects of reperfusion. This phenomenon, ...
Dual Antibody Functionalized Polyvinyl Alcohol and Alginate Hydrogels for Synergistic Endothelial Cell Adhesion
(2012-07-27)
Motivated by the need to design minimally-invasive treatments for wide-necked cerebral aneurysms, we used computational modeling to assess aneurysm hemodynamics, examined in vitro cellular responses arising from mechanical ...
Photonic Crystal Nanobeam Cavities for Biomedical Sensing
(2012-07-20)
Manipulation of light at the nanoscale has the promise to enable numerous technological advances in biomedical sensing, optical communications, nano-mechanics and quantum optics. As photons have vanishingly small interaction ...
Extracting Spatiotemporal Word and Semantic Representations from Multiscale Neurophysiological Recordings in Humans
(2012-09-13)
With the recent advent of neuroimaging techniques, the majority of the research studying the neural basis of language processing has focused on the localization of various lexical and semantic functions. Unfortunately, ...
Dissecting Motor Adaptation in Visually Guided Reaching Movements
(2012-11-06)
Movement is essential to human life because it provides us with the freedom of mobility and the power to affect our surroundings. Moreover, movements are vital to communication: from hand and finger movements when writing, ...