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Understanding the Cellular Ecology of Mtb Granulomas Using Single-Cell Sequencing
(2020-05-14)
Infection with Mycobacterium tuberculosis (Mtb) results in the formation of pulmonary granulomas, which are complex structures comprised of variable mixtures of stromal, parenchymal and immune cells. While Mtb granulomas ...
Characterizing Ebola virus mutation and selection between and within hosts
(2020-04-01)
Ebola virus (EBOV), a causative agent of Ebola virus disease (EVD), has re-emerged as a serious threat to human health. The recent 2013–2016 EVD epidemic in Western Africa and the ongoing outbreak in the Democratic Republic ...
Maintaining Subtype-Specific Neuronal Identity in the Mammalian Cerebral Cortex
(2020-04-29)
In the mammalian cerebral cortex, distinct classes of neurons are generated embryonically and maintain their subtype-specific identities throughout the lifetime of the organism. While their developmental programs have begun ...
CRISPR Activation Screening of Circulating Tumor Cells Identifies Enhancers of Blood-Based Metastasis
(2020-01-28)
Over ninety percent of cancer mortality is attributable to metastasis, most commonly due to the blood-borne dissemination of cancer cells from a primary tumor to secondary tissues. However, the vast majority of these cancer ...
Oncogenic K-Ras Alleles and Their Genetic Interactors in Mouse Models of Colorectal Cancer
(2020-05-14)
KRAS (Kirsten rat sarcoma) oncoprotein is mutationally activated in ~40% of colorectal cancers (CRC) and KRAS mutation state is an excellent predictor of the failure of a cancer to respond to conventional chemotherapy or ...
Genome-Wide Screen Identifies RTF2 as a Host Restriction Factor That Restricts Influenza A Virus Replication
(2020-05-12)
Viral infection triggers the secretion of type I interferons, which in turn induce expression of hundreds of genes. However, the roles and molecular mechanisms of these induced genes in the context of antiviral immunity ...
Defining the Roles of the Microtubule-Associated Protein TACC in Drosophila Synapse Development
(2020-04-06)
The development of the synapse, the essential functional unit of the nervous system, is a highly regulated process underlying neuronal circuitry and plasticity. Following axon pathfinding, complex signaling networks ...
Cellular and Circuit Dynamics Underlying Circadian Timekeeping
(2020-05-11)
Circadian clocks internally represent the passage of each day, and organize physiology and behavior to align with changing external conditions. The central organizers of circadian rhythms are molecular oscillators that ...
Probabilistic Models of Larval Zebrafish Behavior Reveal Structure on Many Scales
(2020-05-12)
Nervous systems have evolved to combine environmental information with internal state to select and generate adaptive behavioral sequences. To better understand these computations and their neural implementation, natural ...
Neural Basis for Regulation of Vasopressin Secretion by Presystemic Anticipated Disturbances in Osmolality, and by Hypoglycemia
(2020-05-12)
Vasopressin (AVP), released by magnocellular AVP neurons of the hypothalamus, is a multifaceted hormone. AVP regulates many physiological processes including blood osmolality, blood glucose, and blood pressure. In this ...