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Now showing items 11-20 of 225
I. Engaging Cationic Intermediates in Asymmetric Catalysis: Enantioselective Reactions of Carbenium Ions and N,N-Dialkyliminium Ions II. Enantioselective Catalysis of the Cope-Type Hydroamination by H-Bond Donors
(2013-09-16)
The research described here explores the ability of dual H-bond donor catalysts to induce asymmetry in a variety of synthetically useful transformations that proceed via diverse reactive intermediates. In Chapters 1-3, ...
Development of Earth-Abundant Tin(II) Sulfide Thin-Film Solar Cells by Vapor Deposition
(2013-09-18)
To sustain future civilization, the development of alternative clean-energy technologies to replace fossil fuels has become one of the most crucial and challenging problems of the last few decades. The thin film solar cell ...
Unconventional Strategies to Target Challenging Enzymes Using Small-Molecule Covalent Inhibitors
(2013-10-08)
Unconventional strategies employing covalent small molecules were investigated to down-regulate signaling pathways mediated by enzymes that are challenging to target. First, Her3 was selectively degraded using covalent ...
Sensing Inorganic Phosphate Starvation by the Phosphate-Responsive (PHO) Signaling Pathway of Saccharomyces cerevisiae
(2013-09-30)
Inorganic phosphate \((P_i)\) is an essential nutrient whose intracellular levels are maintained by the PHO pathway in Saccharomyces cerevisiae. \(P_i\) limitation triggers upregulation of the PHO genes whose gene products ...
Total Syntheses of Fastigiatine and the Hibarimicin Aglycons
(2013-10-07)
Part one of this two-part thesis describes my efforts toward the total syntheses of the complex polycyclic alkaloids himeradine A and fastigiatine, which are members of the Lycopodium family of natural products. A cascade ...
Total Synthesis of (−)-Nakadomarin A
(2013-10-18)
A convergent and scalable total synthesis of polycyclic manzamine alkaloid (-)-nakadomarin A is described. Unsaturated bicyclic lactam fragment A was prepared from acrolein in 5 steps, and macrolactam fragment B was prepared ...
First-Row Transition Metal Complexes of Dipyrrinato Ligands: Synthesis and Characterization
(2013-10-15)
A library of variously-substituted dipyrrins and their first-row transition metal (Mn, Fe, Cu, Zn) complexes have been synthesized, and the effects of peripheral substituents on the spectroscopic, electrochemical, and ...
Total Synthesis of Hyperforin
(2013-10-17)
Hyperforin is the component of the medicinal herb St. John's Wort (Hypericum perforatum) responsible for its antidepressant activity. It works by blocking the reuptake of a variety of neurotransmitters through a unique ...
The Biochemistry and Physiology of Peptidases
(2013-03-14)
Peptidases regulate important physiological processes by controlling levels of bioactive peptides and occasionally through noncatalytic processes. This thesis presents a study of prolyl endopeptidase-like (PREPL), which ...
Exciton Transfer in Photosynthesis and Engineered Systems: Role of Electronic Coherence and the Environment
(2013-02-11)
Recent experiments show evidence for long-lived electronic coherence in several photosynthetic complexes, for example in the Fenna-Matthews-Olson complex of green sulfur bacteria. The experiments raise questions about the ...