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Now showing items 11-19 of 19
The Genetics of Cortical Folding Disorders: From Mechanisms to Diagnosis
(2022-06-06)
Gyration is a feature of many mammalian neocortices; though the developmental mechanisms that produce cortical gyri are poorly understood. Defects in gyrification can lead to polymicrogyria, a congenital cortical malformation ...
Development of bipolar interneuron subtypes within the retinal space-time continuum
(2022-01-18)
Development of the retina requires precise production of more than 100 neuronal subtypes.
How does such diversity emerge during development at the perfect time and place to create functional
circuitry? Recent molecular ...
Neurochemically distinct median raphe subsystems: unique hodology and presynaptic specializations
(2021-11-16)
From their somata residing in the brainstem, neurons expressing the master serotonergic regulator gene Pet1 (aka Fev) extend axonal projections to forebrain regions underlying such diverse functions as sleep, memory, ...
Cell states and neuronal vulnerabilities in neurodegenerative diseases
(2022-09-14)
Neurodegenerative diseases are pathologically characterized by the induction of gliotic states and the loss of specific neurons in the human brain. A precise ascertainment of cellular states altered and those types of ...
The activity-dependent FOS regulon in stem cell-derived human neurons
(2023-06-01)
Cells integrate signals from the environment by activating gene programs that mediate the cells’ response to extracellular stimuli. This process is largely initiated by activation of distinct sets of immediate early genes ...
The Role of miRNA in Activity-Dependent Synaptic Plasticity
(2023-05-16)
During processes like learning and memory, neural activity dynamically remodels synaptic connectivity which is critical for adaptive behavior and memory storage. At the molecular level, regulatory control of transcription ...
Quantitative analysis of clonal architecture across the human cerebral cortex using somatic mutations
(2021-07-12)
The human cerebral cortex shows remarkable functional specialization into regions devoted to motor, sensory, or visual functions, and these functional areas correlate with dramatic differences in cellular composition, or ...
Chromatin Regulation of Transcriptional Repression in the Developing Brain
(2024-03-12)
The complex organization of the brain is enabled by the precise coordination of developmental and activity-dependent gene programs. Mechanisms acting at the level of chromatin play a key role in promoting, repressing, or ...
Functional genomic dissection of human brain development, degeneration, and dysfunction in pediatric neurogenetic disorders
(2023-09-13)
Human disease genetics has implicated hundreds of genes in brain development, maintenance, and function. Experimentally tractable animal models and culture systems have contributed greatly to understanding the function of ...