Search
Now showing items 21-30 of 618
Role of ATM in Suppressing Oncogenic Translocations and Mature B Cell Lymphomas
(2014-02-25)
The ATM protein senses DNA double-stranded breaks (DSBs) and facilitates proper repair. B and T lymphocytes of ATM-deficient patients have increased antigen receptor locus translocations associated with aberrant V(D)J ...
The Role of Dendritic Cell Subsets in Cross-presentation and Stimulation of Homing Marker Expression
(2014-02-25)
Topical antigen (Ag) application mimics natural Ag exposure across the skin. Soluble Ag introduced through this route requires cross-presentation by dendritic cells (DCs) to generate CD8 T cell responses, including skin-homing ...
Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid
(2014-02-25)
Following human immunodeficiency virus (HIV-1) entry into the host cell, the viral capsid gradually disassembles in a process called uncoating. A proper rate of uncoating is important for reverse transcription of the HIV-1 ...
The Roles of RNA-binding Proteins in the Developing Nervous System
(2014-02-25)
RNA-binding proteins are key players in post-transcriptional regulation of gene expression by orchestrating RNA fate from synthesis to decay. Hundreds of proteins with RNA-binding capacity have been identified so far, yet ...
Visualizing Influenza Virus Membrane Fusion: Inhibition and Kinetics
(2014-02-25)
The influenza virus hemagglutinin (HA) surface protein is a primary antigenic target for neutralization of viral infection. HA also mediates membrane fusion between the virus and a cell, which is the first critical step ...
Adipose tissue FABP deficiency promotes metabolic reprogramming and positively impacts healthspan
(2014-02-25)
The adipose tissue lipid chaperones aP2 and mal1, also known as fatty acid binding proteins (FABPs), are significant molecules contributing to metabolic homeostasis, whereby their absence promotes physiological changes ...
Memory in a phenotypic switch and noise in gene networks
(2014-02-25)
Many cell types stochastically switch phenotypes under some conditions, so that genetically identical sister cells may behave quite differently in a common environment. This non-genetic variability likely arises from noise ...
Quantifying Methane Emissions Using Satellite Observations
(2014-02-25)
Methane is the second most influential anthropogenic greenhouse gas. There are large uncertainties in the magnitudes and trends of methane emissions from different source types and source regions. Satellite observations ...
Tracing human cancer evolution with hypermutable DNA
(2014-02-25)
Metastasis is the main cause of cancer morbidity and mortality. Despite its clinical significance, several fundamental questions about the metastatic process in humans remain unsolved. Does metastasis occur early or late ...
Low Speed Avian Maneuvering Flight
(2014-02-25)
Low speed avian maneuvering flight is an ecologically crucial behavior that has contributed to the explosive diversification of several avian taxa by allowing access to complex spatial environments. Negotiating a sharp ...