Now showing items 21-30 of 617
Next-Generation Population Genomics: Inversion Polymorphisms, Segregation Distortion and Fitness Epistasis
Although population genetics has a long history and firm theoretical basis, until recently little data was available for empirical hypothesis testing. The unprecedented growth of sequencing methodologies has transformed ...
Improved Thin Film Solar Cells Made by Vapor Deposition of Earth-Abundant Tin(II) Sulfide
Tin(II) sulfide (SnS) is an earth-abundant, inexpensive, and non-toxic absorber material for thin film solar cells. SnS films are deposited by atomic layer deposition (ALD) through the reaction of a tin precursor, ...
Dilemmas in Design: From Neyman and Fisher to 3D Printing
This manuscript addresses three dilemmas in experimental design.
Profiling and Improving the Specificity of Site-Specific Nucleases
Programmable site-specific endonucleases are useful tools for genome editing and may lead to novel therapeutics to treat genetic diseases. TALENs can be designed to cleave chosen DNA sequences. To better understand TALEN ...
The Role of Microenvironmental Cues in Cardiomyogenesis and Pathogenesis
The cellular microenvironment consists of soluble and insoluble factors that provide signals that dictate cell behavior and cell fate. Limited characterization has hindered our ability to mimic the physiological or ...
An evolutionary perspective on germ cell specification genes in insects
This dissertation investigates the embryonic specification of a specific group of cells: the germ cells. Germ cells, which give rise to sperm and egg, are the only cells in sexually-reproducing animals that directly ...
Post-Genomic Approaches to Personalized Medicine: Applications in Exome Sequencing, Microbiome, and COPD
Since the completion of the sequencing of the human genome at the turn of the century, genomics has revolutionized the study of biology and medicine by providing high-throughput and quantitative methods for measuring ...
LEARNING-RELATED CHANGES IN THE FUNCTIONAL CONNECTIVITY WITHIN THE ZEBRA FINCH SONG-CONTROL CIRCUIT
Many species-specific sensorimotor behaviors, such as speech in humans, emerge from the interplay between genetically defined developmental programs and sensory experience. How these processes interact during learning to ...
Structure-Function Analysis of the Conserved Histone Chaperone Spt6
Chromatin structure is crucial to regulate access to the genome for processes such as a transcription, recombination, DNA repair, and DNA replication. Spt6, a key factor involved in regulating chromatin structure, is ...
The Ethos of Language and the Ethical Philosophy of Odysseus Elytis
My dissertation deals with the ethical philosophy of the Greek poet and Nobel Prize winner Odysseus Elytis (1911-1996). Responding to the "ethical turn" in literary scholarship, I scrutinize the notion of ethos and ethics, ...