Now showing items 21-30 of 617
The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
Epithelial-mesenchymal transition (EMT) is a fundamental developmental program, which is believed to be reactivated during the progression of in situ carcinoma to aggressive metastatic cancers. Ras-ERK pathway has been ...
Essays in Access to Civil Justice
In this three-article dissertation, I explore access to civil justice issues from several dimensions. Existing data tells us that poor households are significantly less likely than moderate- and high-income households to ...
SNP-set Tests for Sequencing and Genome-Wide Association Studies
In this dissertation we propose methodology for testing SNP-sets for genetic associations, both for sequencing and genome-wide association studies. Due to the large scale of this kind of data, there is an emphasis on ...
Integrative Characterization of Human Long Non-Coding RNAs
Since its early discovery as a messenger, RNA has been shown to play a diverse set of regulatory, structural and even catalytic roles. The more recent understanding that the genome is pervasively transcribed stimulated the ...
LYSOSOMAL DESTABILIZATION IN RETINAL PIGMENT EPITHELIAL CELLS ACTIVATES THE NLRP3 INFLAMMASOME AND INDUCES IL-1β SECRETION
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness, affecting over 30 million people worldwide. It is characterized by the appearance of insoluble deposits known as drusen in the ...
Reprogramming Pediatric Genetic Disorders: Pearson Syndrome, Ring 14 Syndrome, and Fanconi Anemia
The effect of a single genetic mutation can vary greatly between different types of cells. The mutated gene may not be expressed in one tissue but may cause a devastating loss of function in another. To learn about disease ...
Study on Bacterial Protein Synthesis System toward the Incorporation of D-Amino Acid & Synthesis of 2'-deoxy-3'-mercapto-tRNA
Life is anti-entropic and highly organized phenomenon with two characteristics reinforcing each other: homochirality and the stereospecific catalysis of chemical reactions. The exclusive presence of L-amino acids and ...
Modulation of small RNA silencing by cross-generational signaling in C. elegans
Organisms are constantly challenged by the surrounding environment and alter their physiology accordingly. Some environment-induced changes in one generation are inherited in the offspring, and this long-lasting memory of ...
No Metaphysics within Physics?
This dissertation has three parts. In "Quantum Entanglement, Bohmian Mechanics, and Humean Supervenience," I defend David Lewis's metaphysical doctrine of Humean supervenience, and traditional metaphysical reductionism ...
Statistical Methods for Aggregation of Indirect Information
How to properly aggregate indirect information is more and more important. In this dissertation, we will present two aspects of the issue: indirect comparison of treatment effects and aggregation of ordered-based rank data.