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Genetic Basis of Metabolic Evolution in the Cave Fish Astyanax Mexicanus
(2018-05-12)
Organisms evolve to thrive in new environments. In spite of the role metabolism plays in adaptation, the genetic basis for metabolic variation remains poorly understood. Here we use independently derived populations of ...
Extending the Reach of Coevolution-Based Protein Residue-Residue Contact Prediction
(2018-08-17)
The three-dimensional conformations of macromolecules are critical to their diverse functions; however, many important proteins have as yet undetermined structures. Structural states are constrained by residue-residue ...
Intestinal Complement Modulates Colitis by Targeting the Gut Microbiota
(2018-01-22)
The proteins that make up the immune effector system known as complement are synthesized by hepatocytes and are present at high levels in the bloodstream. Serum complement not only displays antimicrobial activities such ...
Mechanisms of Intensity Encoding for Non-Image-Forming Visual Functions
(2018-01-18)
Light drives many physiological processes that exist outside conscious awareness. These ‘non-image-forming’ visual functions are typically sensitive to the overall environmental light intensity—a parameter which can vary ...
Functional Characterization of Netrin-1 and Its Role in CNS-PNS Boundary Maintenance in the Developing Vertebrate Brainstem
(2018-05-01)
Netrin-1 (Ntn1) has represented the archetype of diffusible guidance cues since its discovery in the 1990s. It is often depicted in a gradient emanating from the floor plate of the embryonic neural tube, through which it ...
Computational and Statistical Methods for Characterizing Single-Cell Heterogeneity
(2018-01-19)
The emergence of single-cell technologies has highlighted the potential to discover novel cellular subpopulations and states within heterogeneous populations. Such technologies are achieving increasingly higher-throughput, ...
Mechanisms of Scale Invariance in Embryonic Patterning Systems
(2018-05-10)
Embryos pattern themselves with remarkable consistency and readily adjust their patterning programs to drastic changes in embryo size. This robustness of pattern formation, termed scale invariance, requires cells to determine ...
The Contribution of Hippocampal Oxytocin Receptors to Social Memory Processing
(2018-05-12)
Recent studies have highlighted growing evidence that the hippocampus assumes an underappreciated role in promoting social memories. However, the mechanisms by which discrimination of social and non-social stimuli are ...
Directed evolution of Cas9 for mammalian genome editing
(2018-05-14)
The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...
Control of Drosophila Courtship by Mating Drive
(2018-09-16)
Most behaviors are not just actions and reactions, but are the result of self-evaluation and are the means of self-fulfillment. This means that the same external context (e.g. food) can hold different meaning to an animal ...