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Now showing items 21-28 of 28
Investigating the Rates and Drivers of Drug Resistance in Mycobacterium Tuberculosis
(2015-05-11)
The emergence and transmission of drug resistant strains of Mycobacterium tuberculosis (Mtb) calls for urgency in understanding the barriers to effective treatment. Here we developed a chemostat cultivation system to ...
TRIM22 IS A NOVEL RESTRICTION FACTOR OF HERPESVIRUSES
(2015-05-13)
The host response to the family of nuclear replicating DNA viruses or the herpesviruses includes the intrinsic, innate and adaptive arms of the immune system. Intrinsic resistance is a constitutively active line of defense ...
The Contribution of Cervicovaginal Microbiota and Hormonal Contraceptives to Genital Inflammation and HIV Acquisition Risk
(2015-05-17)
The HIV epidemic persists in many parts of the world, with the majority of new infections occurring through the female genital tract (FGT). The permissiveness of the genital mucosa to HIV is modulated by the integrity of ...
Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio Cholerae Chromosome
(2015-05-16)
Vibrionaceae family members are interesting models for studying DNA replication initiation as they contain two circular chromosomes. Chromosome II (chrII) replication is governed by two evolutionarily unique, yet highly ...
Spatiotemporal Control of Mycobacterium Tuberculosis Cell Wall Biogenesis by the Peptidoglycan Synthase PonA1
(2015-05-04)
Mycobacterium tuberculosis causes one of the most pernicious infectious diseases of humankind – tuberculosis, which is still a global problem in the 21st century. Drug-resistant M. tuberculosis infections are on the rise, ...
Disentangling the Coevolutionary Histories of Animal Gut Microbiomes
(2015-05-17)
Animals associate with microbes in complex interactions with profound fitness consequences. These interactions play an enormous role in the evolution of both partners, and recent advances in sequencing technology have ...
Investigating Host Protein Function and Developing Assays for Influenza Virus Infection
(2015-04-08)
With eight genomic segments encoding at least thirteen proteins, influenza virus can subvert a cell into a virus-producing factory. To study influenza infection, I utilize versatile fluorescent-based technologies to ...
Enterococcus infection of Caenorhabditis elegans as a model of innate immunity
(2015-05-14)
The vast majority of metazoan species are invertebrates, which lack an adaptive immune system for defense against microbes. Instead, their innate immune system is sufficient for defense against pathogenic organisms, which ...