A library of variously-substituted dipyrrins and their first-row transition metal (Mn, Fe, Cu, Zn) complexes have been synthesized, and the effects of peripheral substituents on the spectroscopic, electrochemical, and ...

Hyperforin is the component of the medicinal herb St. John's Wort (Hypericum perforatum) responsible for its antidepressant activity. It works by blocking the reuptake of a variety of neurotransmitters through a unique ...

Metabolites and peptides have a central role in biology that is often overlooked. Despite the importance of metabolites in key protein-metabolite interactions (PMIs), the extent and identity of these interactions is not ...

Part one of this two-part thesis describes my efforts toward the total syntheses of the complex polycyclic alkaloids himeradine A and fastigiatine, which are members of the Lycopodium family of natural products. A cascade ...

Apoptosis is an intricately regulated cellular process required for the health and homeostasis of living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro- and anti-apoptotic members whose ...

Nature employs complex networks of protein-tailoring enzymes to effect the post-translational modification of proteins in vivo. By comparison, modern chemical methods rely upon either nonspecific labeling techniques or ...

The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex ...

Laboratory directed evolution have enabled the discovery of numerous functional natural and synthetic macromolecules with tailor-made functions. However, approaches that use enzymes to effect the crucial translation from ...

A healthy immune system's core challenge is to mount appropriate responses to an immense and unknown variety of antigenic stimuli. By unraveling the regulatory networks that drive and control immune-cell behaviors, we can ...

Understanding future climate requires observations of trace species that can significantly influence the chemical or radiative properties of the atmosphere. The development of optical instruments, utilizing laser-systems ...