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First-Row Transition Metal Complexes of Dipyrrinato Ligands: Synthesis and Characterization 

Scharf, Austin Bennett (2013-10-15)
A library of variously-substituted dipyrrins and their first-row transition metal (Mn, Fe, Cu, Zn) complexes have been synthesized, and the effects of peripheral substituents on the spectroscopic, electrochemical, and ...
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Total Synthesis of Hyperforin 

Sparling, Brian Andrew (2013-10-17)
Hyperforin is the component of the medicinal herb St. John's Wort (Hypericum perforatum) responsible for its antidepressant activity. It works by blocking the reuptake of a variety of neurotransmitters through a unique ...
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Discovery and Characterization of Novel Bioactive Peptides and a Natural ERRalpha Ligand 

Schwaid, Adam (2013-10-17)
Metabolites and peptides have a central role in biology that is often overlooked. Despite the importance of metabolites in key protein-metabolite interactions (PMIs), the extent and identity of these interactions is not ...
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Total Syntheses of Fastigiatine and the Hibarimicin Aglycons 

Liau, Brian Bor-Jen (2013-10-07)
Part one of this two-part thesis describes my efforts toward the total syntheses of the complex polycyclic alkaloids himeradine A and fastigiatine, which are members of the Lycopodium family of natural products. A cascade ...
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Discovery of bioactive lipids and lipid pathways in cell death and disease 

Zhang, Tejia (2014-06-06)
Apoptosis is an intricately regulated cellular process required for the health and homeostasis of living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro- and anti-apoptotic members whose ...
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Directed Evolution of Sortase Activity and Specificity 

Dorr, Brent Matthew (2014-06-06)
Nature employs complex networks of protein-tailoring enzymes to effect the post-translational modification of proteins in vivo. By comparison, modern chemical methods rely upon either nonspecific labeling techniques or ...
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Component-Based Syntheses of Trioxacarcins 

Smaltz, Daniel Jonathan (2014-06-06)
The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex ...
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Translation of DNA into Evolvable Sequence-Defined Synthetic Polymers 

Niu, Jia (2014-06-06)
Laboratory directed evolution have enabled the discovery of numerous functional natural and synthetic macromolecules with tailor-made functions. However, approaches that use enzymes to effect the crucial translation from ...

Elucidation of immune cell function via nanotechnology and single-cell profiling. 

Gaublomme, Jellert Thomas (2014-06-06)
A healthy immune system's core challenge is to mount appropriate responses to an immense and unknown variety of antigenic stimuli. By unraveling the regulatory networks that drive and control immune-cell behaviors, we can ...
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Development and Deployment of Optical Instruments to Measure Trace Atmospheric Species: I. Water Isotopologues; II. Glyoxal; III. Iodine Monoxide 

O'Brien, Anthony (2012-12-13)
Understanding future climate requires observations of trace species that can significantly influence the chemical or radiative properties of the atmosphere. The development of optical instruments, utilizing laser-systems ...
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  • Chemistry (26)
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  • Organic chemistry (14)
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FAS Department
  • Chemistry and Chemical Biology$:$ (149)
Date Issued
  • 2013 (38)
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Except where otherwise noted, this work is subject to a Creative Commons Attribution 4.0 International License, which allows anyone to share and adapt our material as long as proper attribution is given. For details and exceptions, see the Harvard Library Copyright Policy ©2022 Presidents and Fellows of Harvard College.

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