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Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas
(2014-06-06)
With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted ...
Adaptation and Specialization in the Evolution of Bacterial Metabolism
(2014-06-06)
Specialization is a balance of evolutionary adaptation and its accompanying costs. Here we focus on the Lenski Long-Term Evolution Experiment, which has maintained cultures of Escherichia coli in the same, defined seasonal ...
LYSOSOMAL DESTABILIZATION IN RETINAL PIGMENT EPITHELIAL CELLS ACTIVATES THE NLRP3 INFLAMMASOME AND INDUCES IL-1β SECRETION
(2014-06-06)
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness, affecting over 30 million people worldwide. It is characterized by the appearance of insoluble deposits known as drusen in the ...
Linking Metabolic Rates with the Diversity and Functional Capacity of Endolithic Microbial Communities within Hydrothermal Vent Structures
(2013-10-18)
At hydrothermal vents, thermal and chemical gradients generated by the mixing of hydrothermal fluids with seawater provide diverse niches for prokaryotic communities. To date, our knowledge of environmental factors that ...
Structure and development of Rafflesiaceae
(2013-10-17)
Rafflesiaceae produce the largest flowers among all flowering plants, measuring up to a meter in diameter and weighting 7 kg, and have been a source of amazement since their discovery about two centuries ago. In addition ...
Molecular Dissection of Neural Circuits Underlying Parental Behavior in Mice
(2013-10-18)
Mice display robust and stereotyped behaviors towards pups: virgin males typically attack pups, while virgin females and sexually experienced males display parental care. I show here that virgin males that are genetically ...
Phosphatome RNAi Screen Identifies Eya1 as a Positive Regulator of Hedgehog Signal Transduction
(2013-10-18)
The Hedgehog (Hh) signaling pathway is vital for vertebrate embryogenesis and aberrant activation of the pathway can cause tumorigenesis in humans. In this study, we used a phosphatome RNAi screen for regulators of Hh ...
Evolution of Bivalvia: Multi-level phylogenetic and phylogenomic reconstructions within Bivalvia (Mollusca) with emphasis on resolving familial relationships within Archiheterodonta (Bivalvia: Heterodonta).
(2013-10-15)
With an estimated 8,000-20,000 species, bivalves represent the second largest living class of molluscs (Bieler et al. 2013). Revived interest in molluscan phylogeny has resulted in a torrent of molecular sequence data from ...
Molecular and Circuit Mechanisms of Insulin Signaling in Caenorhabditis elegans
(2014-02-25)
Insulin signaling is highly conserved across animals, and is known for its ubiquitous function in all aspects of animal physiology. Despite its relatively well-studied role in metabolism and energy expenditure, how it is ...
Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis
(2014-06-06)
Faced with an environment of constantly changing nutrient availability, mammals have adapted complex homeostatic mechanisms to maintain energy balance. Deviations from this balance are largely corrected through a concerted, ...