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Coordinate control of virulence gene expression in Francisella tularensis
(2015-05-19)
Francisella tularensis is a Gram-negative, intracellular pathogen and the causative agent of tularemia. Due to its low infectious dose, ability to cause potentially fatal disease, and ability to be easily aerosolized, ...
A novel sigma factor antagonist that binds to RNA polymerase
(2015-05-18)
Sigma (σ) factors direct programs of gene expression by binding to and determining the promoter recognition specificity of RNA polymerase (RNAP). Genes transcribed under the control of alternative σs allow cells to respond ...
A sigma factor and anti-sigma factor that control swarming motility and biofilm formation in Pseudomonas aeruginosa
(2015-05-20)
Pseudomonas aeruginosa is an environmental bacterium and opportunistic human pathogen of major clinical significance. It is the principal cause of morbidity and mortality in patients with cystic fibrosis (CF) and a leading ...
Differential fluorescence-based genetic screens to identify novel Listeria monocytogenes virulence determinants
(2015-01-23)
Listeria monocytogenes is a Gram-positive, facultative intracellular pathogen that causes gastroenteritis, which in the young, the elderly, and the immunocompromised can progress to severe invasive disease with high ...
Mycobacterial Metabolic Syndrome: Triglyceride Accumulation Decreases Growth Rate and Virulence of Mycobacterium Tuberculosis
(2015-01-23)
Mycobacterium tuberculosis (Mtb) mutants lacking the operon Rv1411c-1410c encoding a lipoprotein, Rv1411c (LprG) and a putative transporter, Rv1410c (Rv1410) are dramatically attenuated for growth in mice. Previous work ...
Mechanisms Controlling the Cell Envelope Remodeling Activities of the Escherichia Coli Cytokinetic Ring
(2016-05-13)
In Escherichia coli, cytokinesis requires the constriction of all the cell envelope layers: the inner membrane, the peptidoglycan (PG) cell wall and the outer membrane (OM). Such dramatic cell envelope remodeling requires ...
Disentangling the Coevolutionary Histories of Animal Gut Microbiomes
(2015-05-17)
Animals associate with microbes in complex interactions with profound fitness consequences. These interactions play an enormous role in the evolution of both partners, and recent advances in sequencing technology have ...
The Genetics of Life History Traits in the Fungus Neurospora crassa
(2016-05-13)
The study of life histories is fundamental to understanding why some organisms live for a very short time while others live for a long time, why some produce thousands of offspring while others produce one, or why some ...
Post-Transcriptional Control of Multicellularity in Bacillus subtilis
(2016-05-13)
Bacteria are capable of sensing changes in their environment and responding to those changes by altering patterns of gene expression. There are many mechanisms by which bacteria can sense internal and external signals. The ...
Identification of MltG as a Potential Terminase for Peptidoglycan Polymerization in Bacteria
(2016-05-05)
Bacterial cells are fortified against osmotic lysis by a cell wall made of peptidoglycan (PG). Synthases called penicillin-binding proteins (PBPs), the targets of penicillin and related antibiotics, polymerize the glycan ...