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Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas
(2014-06-06)
With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted ...
Adaptation and Specialization in the Evolution of Bacterial Metabolism
(2014-06-06)
Specialization is a balance of evolutionary adaptation and its accompanying costs. Here we focus on the Lenski Long-Term Evolution Experiment, which has maintained cultures of Escherichia coli in the same, defined seasonal ...
LYSOSOMAL DESTABILIZATION IN RETINAL PIGMENT EPITHELIAL CELLS ACTIVATES THE NLRP3 INFLAMMASOME AND INDUCES IL-1β SECRETION
(2014-06-06)
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness, affecting over 30 million people worldwide. It is characterized by the appearance of insoluble deposits known as drusen in the ...
Molecular and Circuit Mechanisms of Insulin Signaling in Caenorhabditis elegans
(2014-02-25)
Insulin signaling is highly conserved across animals, and is known for its ubiquitous function in all aspects of animal physiology. Despite its relatively well-studied role in metabolism and energy expenditure, how it is ...
Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis
(2014-06-06)
Faced with an environment of constantly changing nutrient availability, mammals have adapted complex homeostatic mechanisms to maintain energy balance. Deviations from this balance are largely corrected through a concerted, ...
Cellular Targets of Propranolol in Infantile Hemangioma
(2014-02-25)
Infantile hemangioma (IH) is a vascular neoplasm that affects 4-10 percent of infants. Propranolol, a non-selective beta-adrenergic receptor (AR) antagonist, was serendipitously discovered to accelerate regression of IH ...
Serum and Glucocorticoid-Regulated Kinase Signaling in Breast Cancer
(2014-02-25)
Oncogenic activating mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI 3-K), are highly prevalent in breast cancer. The protein kinase Akt is considered to be the primary effector ...
Genome Engineering Technologies to Change the Genetic Code
(2014-02-25)
New technologies are making it possible to engineer organisms with fundamentally new and useful properties. In vivo genome engineering technologies capable of manipulating genomes from the nucleotide to the megabase scale ...
The role of Ppargc1álpha in neuronal survival and myelination in the neocortex
(2014-02-25)
The mammalian neocortex contains diverse neuronal and glial cell types. Among them lies an important subclass, the subcerebral projection neurons (SCPN) that project to distant targets like the spinal cord. Aiming at ...
Linking bacterial symbiont physiology to the ecology of hydrothermal vent symbioses
(2014-02-25)
Symbioses between prokaryotes and eukaryotes are ubiquitous in our biosphere, nevertheless, the effects of such associations on the partners' ecology and evolution are poorly understood. At hydrothermal vents, dominant ...