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Clonal analysis of native and malignant hematopoiesis using color barcoding in zebrafish
Hematopoietic stem cells (HSCs) emerge from the dorsal aorta during embryogenesis and sustain lifelong blood production. Over time, HSC clones accumulate mutations that may cause clonal expansion at the expense of normal ...
Temporal Regulation of Chromatin Organization During C. Elegans Embryogenesis
In all eukaryotic cells, the genetic material is organized into a complex structure composed of DNA and protein: chromatin. Organization of chromatin structure in the nucleus influences all functions of the genome including ...