Now showing items 21-25 of 25
Functional analysis of multiple activities associated with the herpes simplex virus-1 DNA polymerase
Of the DNA replication proteins required for herpes simplex virus-1 (HSV-1) viral replication, the catalytic subunit of the DNA polymerase (Pol) has been the most extensively studied, both as a model for Family B polymerases ...
Programming molecular behavior: development and applications of autonomous DNA synthesis cascades
DNA serves many functional roles in living organisms, and dynamic DNA nanotechnology seeks to expand this set of DNA-based behaviors through the rational design of new functions. In the past 20 years, the predictable and ...
Temporal Regulation of Chromatin Organization During C. Elegans Embryogenesis
In all eukaryotic cells, the genetic material is organized into a complex structure composed of DNA and protein: chromatin. Organization of chromatin structure in the nucleus influences all functions of the genome including ...
Engineering High-Precision CRISPR-Cas9 Nuclease and Base Editor Technologies
The human genome, comprising approximately three billion nucleotides separated across 23 chromosomes, contains a vast amount of sequence space encoding instructions for the production of RNA and protein molecules that make ...
Mesendoderm Patterning by Vg1/Nodal Heterodimers
One of the key processes during development is the induction of the mesoderm and endoderm (mesendoderm), which generates the precursors of the heart, liver, gut, pancreas, kidney and other internal organs. Nodal, a member ...