Now showing items 21-25 of 25
Integrating Regulatory Information in Eukaryotic Transcription
Transcriptional regulation is a key determinant of cell differentiation during development. Changes in where and when a gene is expressed can lead to phenotypic variation among individuals, and ultimately to phenotypic ...
Programming molecular behavior: development and applications of autonomous DNA synthesis cascades
DNA serves many functional roles in living organisms, and dynamic DNA nanotechnology seeks to expand this set of DNA-based behaviors through the rational design of new functions. In the past 20 years, the predictable and ...
Optimizing Nanodiscs for Membrane Proteins and Mapping a Translation Initiation Complex
Nanodiscs have been an excellent tool for encouraging biochemists and structural biologists to study membrane proteins. They are composed of a discoidal lipid bilayer and two copies of a membrane scaffold protein (MSP). ...
Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
Temporal Regulation of Chromatin Organization During C. Elegans Embryogenesis
In all eukaryotic cells, the genetic material is organized into a complex structure composed of DNA and protein: chromatin. Organization of chromatin structure in the nucleus influences all functions of the genome including ...