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Modulators of hematopoietic stem cell specification using zebrafish embryo cultures
(2018-05-10)
Hematopoietic stem cells (HSCs) have been used clinically to reconstitute the bone marrow, but half of all patients lack an optimally matched donor marrow. HSCs derived from induced pluripotent stem cells (iPSCs) hold great ...
Microbial Evolutionary Dynamics and Transport on Solid and Liquid Substrates
(2018-05-02)
The interplay between a population's spatial structure and transport can dramatically alter its evolutionary dynamics. In this thesis, we study this interplay by growing microbial range expansions, or microbial colonies ...
Phage Assisted Evolutions for Engineering Biosynthetic Pathways
(2018-05-14)
Phage Assisted Continuous Evolution (PACE) and its derivative techniques are powerful tools for evolving improved and altered enzymatic activities. Prior to this work, no one had demonstrated the applicability of these ...
Clonal analysis of native and malignant hematopoiesis using color barcoding in zebrafish
(2018-01-19)
Hematopoietic stem cells (HSCs) emerge from the dorsal aorta during embryogenesis and sustain lifelong blood production. Over time, HSC clones accumulate mutations that may cause clonal expansion at the expense of normal ...
Essays in Finance and Econometrics
(2018-01-18)
This thesis presents two essays studying the role of banks in financial markets and one which studies statistical inference in matching markets. The first chapter presents a new theory of the role of banks, providing an ...
Several Compactness Results in Gauge Theory and Low Dimensional Topology
(2018-05-13)
This thesis studies several compactness problems in gauge theory and explores their applications is low dimensional topology.
The first chapter studies a connection between taut foliations and Seiberg-Witten theory. Let Y ...
Advances in Statistical Network Modeling and Nonlinear Time Series Modeling
(2018-05-11)
The thesis is composed of two independent topics: statistical network modeling and nonlinear time series modeling. With the increasing demand of network data analysis, we present two statistical network models and inferences, ...
Coding Be eR: Assessing and Improving the Reproducibility of R-Based Research With containR
(2018-06-29)
Reproducibility is the cornerstone of science, and we are in the midst of a reproducibility crisis. Simply sharing the code and data used for obtaining results is o en insu cient for reproducibility; in fact, we show that ...
Methods for Estimating the Health Effects of Exposure to Point Sources of Emissions Using Large-Scale and Diverse Data Sources
(2018-04-30)
There is a well-documented association between exposure to fine particulate matter (PM2.5) and numerous health outcomes, with some evidence suggesting PM2.5 originating from coal combustion may have different health impacts. ...
The Adaptive Logic of Moral Luck: Punishment’s Function Shapes the Processes Supporting It
(2018-01-12)
Moral luck is a peculiar aspect of our moral psychology – why do we condemn unintended outcomes (i.e. accidents)? In this dissertation, I present a novel analysis of moral luck, focusing on the argument that moral luck ...