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Phosphatome RNAi Screen Identifies Eya1 as a Positive Regulator of Hedgehog Signal Transduction
(2013-10-18)
The Hedgehog (Hh) signaling pathway is vital for vertebrate embryogenesis and aberrant activation of the pathway can cause tumorigenesis in humans. In this study, we used a phosphatome RNAi screen for regulators of Hh ...
Structure and Thermoelectric Properties of ZnO Based Materials
(2013-10-18)
The present dissertation investigates the relationship between the structure and thermoelectric properties of ZnO based materials, with a focus on trivalent element doping on engineering the microstructure and altering the ...
Roles for Terminal Uridyl Transferases in the Post-Transcriptional Regulation of Developmental miRNAs
(2013-10-18)
MicroRNAs (miRNAs) are a diverse and evolutionarily conserved class of non-coding RNAs that play a multitude of roles in many branches of eukaryotic biology. The regulation of miRNAs is dynamically controlled both spatially ...
Measurements of Interaction-Driven States in Monolayer and Bilayer Graphene
(2013-10-17)
In materials systems with flat energy bands and limited disorder, interactions among electrons dominate and can dramatically alter physical behavior. Traditionally, two-dimensional electron gases (2DEGs) have offered ...
Probing the Dynamics of Shallow Cumulus Convection
(2013-10-18)
Our limited knowledge of convection and its poor representation in climate models is one of the factors that most hamper our ability to understand and predict the climate system. In this thesis, the dynamics of shallow ...
Patron States: The Decline of Clientelism in the United States and Britain
(2013-10-18)
Why do political parties reduce clientelistic strategies and adopt programmatic competition? While nineteenth-century political parties competed using a variety of clientelistic strategies, the period of 1870--1920 in the ...
Toward Multiplex Genome Engineering in Mammalian Cells
(2013-10-18)
Given the explosion in human genetic data, new high-throughput genetic methods are necessary for studying variants and elucidating their role in human disease. In Chapter I, I will expand on this concept and describe ...
Functional Studies of Candidate Oncogenes in Non-Small Cell Lung Cancer
(2013-10-17)
Cancer is a set of complex genetic diseases driven by diverse genomic alterations. The genomic study of cancer has enabled the discovery of novel, targetable events in almost all cancer types and in turn, has led to the ...
Prediction Markets: Theory and Applications
(2013-10-18)
In this thesis I offer new results on how we can acquire, reward, and use accurate predictions of future events. Some of these results are entirely theoretical, improving our understanding of strictly proper scoring rules ...
Performing Passage: Contemporary Artists Stage the Slave Trade
(2013-10-18)
My dissertation examines the work of George C. Wolfe, August Wilson, Lorna Simpson and Glenn Ligon, theater and visual artists working in the 1980s and 1990s who feature representations of the Middle Passage in their work. ...