Commercially available C57BL/6 mice are widely in biomedical research laboratories. We used whole genome sequencing to identify a homozygous copy number variant that disrupts the function of DOCK2 in a commercially available ...

Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...

This three-paper dissertation studies education systems where decision-making power and funding is shared across different levels of government, their achievement levels and inequality across socieoconomic groups. The ...

This dissertation examines the history of “corporate statehood,” or how Americans have understood the corporation as a governmental institution. In contrast to historical accounts of “corporate personhood,” which describe ...

Innate immunity plays a critical role as an initial barrier to infection. In addition, innate immunity can serve to shape and regulate adaptive immune responses. Therefore, investigating the integration of innate and ...

In Chapter 1, we describe a general strategy for 1,3-oxidation of cyclopropanes using aryl iodine(I–III) catalysis, with emphasis on 1,3-difluorination reactions. These reactions make use of practical, commercially available ...

In this thesis we examine several different approaches for deducing observable signals of new physics. First, we outline a technique to extract useful information about the pattern a neural network has learned to recognize, ...

RNA viruses make up a disproportionate amount of emerging human diseases, largely contribute to agriculture, and are recognized for their important roles in shaping the evolution of life. Metagenomics datasets have emphasized ...

How do parents and youth in American cities understand policing in their everyday lives? This dissertation tackles this question using three cases. The first empirical chapter visits Washington, DC, in 2012-2013. I draw ...

As school leaders, K-12 principals have important and wide-ranging roles in ensuring the overall functioning of their schools. Research has found, for instance, that principals impact student achievement and teacher retention ...