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Now showing items 31-40 of 41
Investigating the Role of Heterogeneity in Breast Cancer and Experimental Design
(2018-08-31)
Breast cancer is predicted to be the most frequent newly diagnosed cancer and second leading cause of cancer-associated death among women in the United States in 2018. Intratumoral heterogeneity plays an important role in ...
Activation and Antagonism of RIG-I-Mediated Innate Immune Signaling by Herpes Simplex Virus 1
(2018-01-16)
The cytosolic innate immune receptor retinoic acid-inducible gene-I (RIG-I) recognizes double-stranded RNA (dsRNA) that emerges during viral infection and initiates an antiviral response comprised of interferon (IFN) and ...
Causality in Epigenetics: Strategies for Targeted Epigenome Engineering of Transcriptional Regulation and Genome Topology
(2018-05-14)
Changes in epigenetic states are at the heart of normal developmental processes and also underlie many human diseases. Studies to date have established strong associations between histone post-translational modifications, ...
Neuropeptides in Neural Circuits and Behavior
(2018-04-19)
Neurons comprise major elements of the nervous system, but do not function in isolation. All nervous system function requires neurons to communicate with each other to integrate, relay, and output information. Neuropeptides ...
Functional analysis of multiple activities associated with the herpes simplex virus-1 DNA polymerase
(2018-05-11)
Of the DNA replication proteins required for herpes simplex virus-1 (HSV-1) viral replication, the catalytic subunit of the DNA polymerase (Pol) has been the most extensively studied, both as a model for Family B polymerases ...
Single-Cell Sequencing and in Vivo Analysis of the Biliary Epithelium Reveal a Dynamic and Essential Role for Yap
(2018-05-13)
The liver, which serves as the main filtration system for the body, is composed of a variety of cell types. Biliary epithelial cells (BECs), an essential cell type within the liver, serve as the main structural component ...
Modulators of hematopoietic stem cell specification using zebrafish embryo cultures
(2018-05-10)
Hematopoietic stem cells (HSCs) have been used clinically to reconstitute the bone marrow, but half of all patients lack an optimally matched donor marrow. HSCs derived from induced pluripotent stem cells (iPSCs) hold great ...
Clonal analysis of native and malignant hematopoiesis using color barcoding in zebrafish
(2018-01-19)
Hematopoietic stem cells (HSCs) emerge from the dorsal aorta during embryogenesis and sustain lifelong blood production. Over time, HSC clones accumulate mutations that may cause clonal expansion at the expense of normal ...
Progress Toward Improved Drug Delivery to the Inner Ear: Methods of Measuring Intracochlear Drug Distribution and Materials-Based Approaches for Controlled Release
(2018-05-13)
Hearing loss is the most common sensory deficit and has a profound impact on quality of life. Despite the emergence of promising therapeutic candidates for hearing restoration, the dearth of safe and efficacious methods ...
Antibody Responses Against HIV-1 Vaccine Candidates
(2018-09-16)
The elicitation of protective antibody responses is likely to be important in developing a successful human immunodeficiency virus type 1 (HIV-1) vaccine. As HIV-1 infection in humans is predominantly transmitted via the ...