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Contribution of SORL1 in human iPSC-derived neurons and astrocytes to Alzheimer’s disease pathogenesis
(2022-09-06)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with heterogeneous etiology as suggested by genetic, neuropathological, and clinical evidence. Induced pluripotent stem cell (iPSC) technology can serve ...
Understanding How Environmental Dynamics and Uncertainty Affect Adaptive Changes in Motor Planning
(2022-03-18)
The elegance and vigor of movements that organisms repeatedly display belie the incredible challenge of controlling these movements. Remarkably, the motor system can achieve smooth and robust motor control undeterred by ...
Genetic and behavioral state influences on the hippocampal spatial code
(2022-06-06)
The hippocampus encodes and recalls contextual memories using engrams and forms spatial memories using place cells. Engrams are typically identified by the expression of the immediate early gene Fos, while place cells are ...