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Now showing items 31-40 of 66
Non-Canonical Translation in Vertebrates
(2015-05-18)
Translation is a key process during gene expression: to produce proteins, ribosomes translate the coding sequences of mRNAs. However, vertebrate genomes contain more translation potential than these annotated coding ...
Convergent Excitatory Pathways Mediate the Zebrafish Escape Behavior
(2015-05-14)
Scientists have long been fascinated by how anatomical structures in the brain can generate the diversity of behaviors apparent in the animal kingdom. While the ultimate goal of neuroscience is to understand complex brain ...
Genetics and Regulation of Bacterial Biofilms
(2015-03-24)
Bacterial biofilm formation, the construction of dense, protective, multicellular communities, is a widely conserved behavior. In some bacteria, such as the Gram-positive model organism Bacillus subtilis, the genetics ...
On Clocks and Tuners: Cyanobacterial Strategies to Thrive in a Dynamic Environment
(2018-01-05)
The cycle of day and night is among the most recurrent and predictable environmental changes. In order to thrive, organisms across all domains of life evolved regulatory strategies to respond to diurnal fluctuations in ...
Integrating Regulatory Information in Eukaryotic Transcription
(2018-08-17)
Transcriptional regulation is a key determinant of cell differentiation during development. Changes in where and when a gene is expressed can lead to phenotypic variation among individuals, and ultimately to phenotypic ...
Structural and Biochemical Studies of RNA Domains Involved in Regulation of Transcriptional Elongation of the HIV-1 retrovirus and Translational Recoding of the SARS Coronavirus
(2017-05-18)
Stable RNA structures interact with proteins at a frequency that allows for regulation of cellular and viral processes. Using a combination of Nuclear Magnetic Resonance (NMR), Small Angle X-Ray Scattering, Mass-Spectrometry ...
Investigation of the Gene Expression Dynamics of Early Mammalian Germ Layer Differentiation
(2017-11-02)
The mechanisms regulating the timing of developmental processes are poorly understood. To systematically investigate the timing of development and its underlying mechanisms, the dynamics of development must first be ...
Establishment and Control of Behavioral Bias in Drosophila Melanogaster
(2018-05-13)
Typically, variability observed across populations of animals is considered to be experimental noise. However, it is clear that individuals display considerable idiosyncrasies in behavior that are stable over both short ...
Genetic Basis of Natural Variation in Cellular Decision Making in Wild Yeasts
(2018-05-15)
In nature, microbes often need to decide which of many potential nutrients to consume. This decision-making process is complex, involving both intracellular constraints and the organism’s perception of the environment. ...
Why WhiB1: Manipulation of Clp System to Determine Role of WhiB1 in Regulating Mycobacterial Cell Division
(2017-05-10)
Mycobacterium tuberculosis (Mtb) is the causal agent of tuberculosis (TB), a major public health issue in the world. In the 2015 WHO report, there were approximately 10.4 million new cases of TB worldwide and 1.4 million ...