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Now showing items 31-40 of 225
Development and Deployment of Optical Instruments to Measure Trace Atmospheric Species: I. Water Isotopologues; II. Glyoxal; III. Iodine Monoxide
(2012-12-13)
Understanding future climate requires observations of trace species that can significantly influence the chemical or radiative properties of the atmosphere. The development of optical instruments, utilizing laser-systems ...
Progress toward the Total Synthesis of Lomaiviticins
(2012-12-20)
A synthetic plan for the dimeric diazobenzofluorene natural product lomaiviticin A and lomaiviticin B is presented. The route features a late-stage oxidative enolate dimerization of a monomeric oxanorbornanone, as well as ...
Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome
(2013-02-19)
The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose ...
Elucidation of the Cation−π Interaction in Small-Molecule Asymmetric Catalysis
(2013-10-14)
The cation–π interaction has been long-established to play an important role in molecular recognition, supramolecular chemistry, and molecular biology. In contrast, its potential application in small-molecule ...
I. Stereoselective Construction of Polycyclic Architectures: Enantioselective Catalytic Transannular Ketone-Ene Reactions and an Enantioselective Total Synthesis of (+)-Reserpine II. Synthesis of Chiral Bisthioureas for Anion-Abstraction Catalysis
(2013-10-18)
The research presented herein explores three aspects of asymmetric catalysis: (1) the development of new catalytic enantioselective reactions, (2) the application of stereoselective catalysis to natural product total ...
Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines
(2012-08-10)
The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the ...
Studies towards a Solution Structure of the Peptidoglycan Glycosyltransferases
(2012-09-13)
Peptidoglycan glycosyltransferases (PGTs) are highly conserved bacterial enzymes that catalyze the polymerization of the lipidic disaccharide, Lipid II, to form individual peptidoglycan (PG) strands which are subsequently ...
Label-Free Optical Imaging of Chromophores and Genome Analysis at the Single Cell Level
(2012-11-01)
Since the emergence of biology as a quantitative science in the past century, a lot of biological discoveries have been driven by milestone technical advances such as X-ray crystallography, fluorescence microscopy and ...
Metal-Ligand Multiple Bonds in High-Spin Complexes
(2012-07-23)
The chemistry of late first row transition metals supported by dipyrromethane and dipyrromethene ligands bearing sterically bulky substituents was explored. Transition metal complexes (Mn, Fe, Co, Ni, Zn) of the dipyrromethane ...
Chemical Vapor Deposition of Thin Film Materials for Copper Interconnects in Microelectronics
(2012-07-24)
The packing density of microelectronic devices has increased exponentially over the past four decades. Continuous enhancements in device performance and functionality have been achieved by the introduction of new materials ...