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Progress toward the Total Synthesis of Lomaiviticins 

Lee, Hong Geun (2012-12-20)
A synthetic plan for the dimeric diazobenzofluorene natural product lomaiviticin A and lomaiviticin B is presented. The route features a late-stage oxidative enolate dimerization of a monomeric oxanorbornanone, as well as ...

Exciton Transfer in Photosynthesis and Engineered Systems: Role of Electronic Coherence and the Environment 

Rebentrost, Frank (2013-02-11)
Recent experiments show evidence for long-lived electronic coherence in several photosynthetic complexes, for example in the Fenna-Matthews-Olson complex of green sulfur bacteria. The experiments raise questions about the ...

Metabolomics Strategies for Discovery of Biologically Active or Novel Metabolites 

Vinayavekhin, Nawaporn (2013-02-08)
Along with genes and proteins, metabolites play important roles in sustaining life. There remains much to be learned about the in vivo roles of metabolites. Metabolomics is a comparative tool to study global metabolite ...

Nanowires as Optoelectronic and Photonic Elements 

Yu, Chun Liang (2013-02-08)
Integrated photonic circuits require small photonic elements. Recent progress in nanowire synthesis and nanofabrication enables us to investigate the potential of nanowires in novel integrated photonic devices. This thesis ...

Using Live Cell Imaging to Probe Biogenesis of the Gram-Negative Cell Envelope 

Yao, Zhizhong (2013-02-08)
In Gram-negative bacteria, the three-layered cell envelope, including the cell wall, outer and inner membranes, is essential for cell survival in the changing, and often hostile environments. Conserved in all prokaryotes, ...
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Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery 

Wang, Yikai (2012-12-19)
In efforts to search for tool compounds that are capable of probing normal and disease-associated biological processes, both quality and identity of the screening collection are very important. Towards this goal, ...

Small-Molecule Modulators of Pancreatic Ductal Cells: Histone Methyltransferases and \(\beta\)-Cell Transdifferentiation 

Yuan, Yuan (2013-03-06)
Small molecules are important not only for treating human diseases but also for studying disease-related biological processes. This dissertation focuses on the effects of small molecules on pancreatic ductal adenocarcinoma ...

Free Radicals and Reactive Intermediates in the Boundary Layer: Development and Deployment of Solid-State Laser Based Instrumentation to Measure Part per Trillion Mixing Ratios of Iodine Monoxide and Glyoxal In Situ 

Thurlow, Meghan Elizabeth (2013-03-18)
Advances in spectroscopic measurement techniques enabling highly accurate measurements of trace gases in the atmosphere are critical for furthering our understanding of the chemical processes that impact both climate and ...
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Small-Molecule Suppressors of Cytokine-Induced Beta-Cell Apoptosis 

Chou, Danny Hung-Chieh (2013-01-02)
Type-1 diabetes is caused by the autoimmune destruction of insulin-producing beta cells in the pancreas. Beta-cell apoptosis involves a complex set of signaling cascades initiated by \(interleukin-1\beta (IL-1\beta)\), ...

Reactions of Diketones and N-Allenoyloxazolidinones Catalyzed by Metal-Bis(oxazoline) Complexes 

Luanphaisarnnont, Torsak (2013-02-25)
This dissertation describes the investigation of the utility of metal–bis(oxazoline) complexes in catalytic asymmetric reactions. The development of Cu(II)-catalyzed regio- and enantioselective additions of silylketenthioacetals ...
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  • Chemistry and Chemical Biology$:$ (149)
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