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In search of breast cancer cell secretions with therapeutic and diagnostic value.
(2014-06-06)
The first end point of this study was to identify specific pro-apoptotic or anti-proliferative factors in the breast cancer cell secretome. To this end, we designed an in vitro screen that effectively cross-cultured 20 ...
Optical control of mammalian endogenous transcription and epigenetic states
(2014-06-06)
The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates ...
Imaging Pressure, Cells and Light Fields
(2014-06-06)
Imaging systems often make use of macroscopic lenses to manipulate light. Modern microfabrication techniques, however, have opened up a pathway to the development of novel arrayed imaging systems. In such systems, ...
Femtosecond-laser hyperdoping and texturing of silicon for photovoltaic applications
(2014-06-06)
This dissertation explores strategies for improving photolvoltaic efficiency and reducing cost using femtosecond-laser processing methods including surface texturing and hyperdoping. Our investigations focus on two aspects: ...
Limiting Disclosure in Annotated Graphs
(2014-06-06)
Data is increasingly represented in annotated graphs, but graphs pose novel security and privacy challenges that at present lack solutions. We begin by identifying the new challenges graphs introduce and explain why existing ...
Ultra-thin solid oxide fuel cells: materials and devices
(2014-06-06)
Solid oxide fuel cells are electrochemical energy conversion devices utilizing solid electrolytes transporting O2- that typically operate in the 800 - 1000 °C temperature range due to the large activation barrier for ionic ...
Peak Sidelobe Level Distribution Computation for Ad Hoc Arrays using Extreme Value Theory
(2014-02-25)
Extreme Value Theory (EVT) is used to analyze the peak sidelobe level distribution for array element positions with arbitrary probability distributions. Computations are discussed in the context of linear antenna arrays ...
Density-Based Separations in Aqueous Multiphase Systems: Tools for Biological Research and Low-Cost Diagnostics
(2014-06-06)
Cells often exist in heterogeneous mixtures. Density provides a property to separate several types of cells from the mixed sample in which they originate. Density-based separation methods provide a standard method to ...
Self-Assembly of Colloidal Spheres with Specific Interactions
(2014-06-06)
In this thesis, I discuss engineering colloidal particles to have specific, isotropic interactions and studying their cluster geometries in equilibrium. I discuss light scattering experiments showing that a highly specific ...
Computations and Algorithms in Physical and Biological Problems
(2014-06-06)
This dissertation presents the applications of state-of-the-art computation techniques and data analysis algorithms in three physical and biological problems: assembling DNA pieces, optimizing self-assembly yield, and ...