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Mechanisms and Vulnerabilities of Mutant SWI/SNF Complexes in Cancer
(2015-05-06)
Genes encoding subunits of the SWI/SNF chromatin remodeling complex are frequently mutated in a wide variety of cancers, but the mechanism of cancer formation following SWI/SNF subunit mutation is not known. As a result, ...
Classical Conditioning Alters Short Noncoding RNA Expression in Drosophila
(2015-05-14)
MicroRNAs (miRNAs) and other classes of short non-coding RNAs regulate essential processes in the development and function of the nervous system. Regulation of miRNAs by neural activity has also been reported. Recently, ...
Diverse Approaches to Developing Combination Therapies for NF1-Mutant Cancers
(2015-05-13)
The NF1 tumor suppressor is lost or mutated in a variety of sporadic cancers, as well as in the hereditary cancer predisposition syndrome neurofibromatosis type 1 (NF1). NF1 patients have an 8–13% risk of developing a ...
Biosensing for Multiplexed Genome Engineering: Applications in Renewable Chemical Production
(2015-05-15)
Engineered biological systems are increasingly used to produce fuels, pharmaceuticals and industrial chemicals. While transforming cells into renewable chemical factories presents an enormous opportunity, development ...
Evolution of sweet taste perception in hummingbirds
(2015-05-17)
Mammals have three members of the small taste receptor gene family responsible for the perception of sweet and savory tastes: two genes (T1R2 and T1R3) comprise the canonical sweet receptor, and a third gene, T1R1, acts ...
VEGF-Dependent Mechanisms Controlling Osteoblast Differentiation and Bone Formation During Bone Repair
(2015-05-05)
Osteoblast-derived vascular endothelial growth factor (VEGF) is important for bone development and postnatal bone homeostasis. Several studies have demonstrated that VEGF affects bone repair and regeneration; however, the ...
Promoter Decoding of Transcription Factor Translocation Dynamics
(2015-05-11)
Many cellular signaling pathways exhibit a bowtie topology: multiple distinct signal inputs converge on a single master transcription factor, which controls the expression of downstream genes. Recent evidence suggests that ...
Engineering Escherichia Coli Fatty Acid Metabolism for the Production of Biofuel Precursors
(2015-05-07)
Medium chain fatty acids (MCFAs, 6-12 carbons) are potential precursors to biofuels
with properties similar to gasoline and diesel fuel but are not native products of Escherichia coli
fatty acid synthesis. Herein we engineer ...
Cell Shape and Treatment Duration: How They Influence a Cancer Cell's Response to TNF
(2016-05-17)
The purpose of my research was to investigate the sources of heterogeneity in cellular decisions that are based on both external and internal cues. I used the signaling network induced by tumor necrosis factor (TNF) as a ...
Discovery and In Vivo Characterization of Long Noncoding RNAs
(2016-05-17)
The noncoding genome, or the portion of the genome that does not encode for proteins, encompasses >95% of the human genome. It has been found that the majority of disease-associated genetic variants identified by genome-wide ...