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Now showing items 31-40 of 119
A Role for Corticothalamic Feedback in Developmental Refinement at the Retinogeniculate Synapse.
(2016-05-16)
The primary image-forming pathway in the mammalian visual system relays information from photoreceptors in the retina through the dorsolateral geniculate nucleus (dLGN) in the thalamus to primary visual cortex (V1). In ...
Neurotoxic Mechanisms of the Chemotherapeutic Paclitaxel
(2016-05-04)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of multiple chemotherapeutic agents for which there are currently no prevention strategies. The widely used chemotherapeutic paclitaxel ...
Biochemical and Genomic Analysis of MeCP2 and Brain-Enriched DNA Methylation
(2016-04-14)
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder with features of autism. MECP2 encodes a methyl-CpG-binding protein that has been proposed to function as a transcriptional repressor, ...
REST and the regulation of stress resistance, brain aging, and Alzheimer’s disease
(2016-02-25)
Understanding how age-related stress in the brain is managed over a lifetime to maintain neuronal and cognitive function and prevent neurodegeneration will be critical for developing therapies to promote healthy aging. ...
The Structure of Mouse Behavior
(2016-05-13)
Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that three-dimensional (3D) mouse pose ...
Bayesian Methods for Discovering Structure in Neural Spike Trains
(2016-05-18)
Neuroscience is entering an exciting new age. Modern recording technologies enable simultaneous measurements of thousands of neurons in organisms performing complex behaviors. Such recordings offer an unprecedented opportunity ...
The Role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in the Neurobiology of Stress-Related Behaviors
(2016-02-24)
Severe or prolonged stress can trigger behavioral signs of psychiatric illnesses including mood and anxiety disorders. Accumulating evidence indicates that stress activates, and in turn is modified by, pituitary adenylate ...
Characterization of Dopamine-Responsive Serotonergic Neurons Underlying Aggression Modulation
(2016-04-04)
The monoaminergic neuromodulatory systems (including the noraderenergic, serotonergic, and dopaminergic neuronal systems) have long been thought of as the custodians of mental health. Dysfunction amongst these neural ...
Hyperactive alpha2-chimaerin reveals the complexity of axon guidance signaling pathways in motor neuron development
(2016-04-14)
α2-chimaerin has striking importance for proper neural circuit formation. Individuals with gain-of-function mutations in α2-chimaerin have Duane retraction syndrome, a common neurogenic eye movement disorder, and α2-chimaerin ...
Regulation of Behavioral Arousal and Quiescence in C. elegans
(2016-05-13)
Animals switch between periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. C. elegans exhibit periods of behavioral quiescence during larval molts (termed lethargus) ...