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Structure-Function Analysis of the Conserved Histone Chaperone Spt6
(2014-06-06)
Chromatin structure is crucial to regulate access to the genome for processes such as a transcription, recombination, DNA repair, and DNA replication. Spt6, a key factor involved in regulating chromatin structure, is ...
At the Heart of the Genome: Rare Genetic Variation, Cardiovascular Disease, and Therapy
(2014-06-06)
Studies of large families with inherited single gene disorders identified a role of rare genetic variation as a cause of disease and enabled gene-based diagnosis. The increasing availability of population-scale genomic ...
The Role of Nuclear Receptor Signaling in Vertebrate Liver Development
(2014-06-06)
Proper embryonic development requires precise genetic regulation of cell growth and differentiation. Organogenesis, the origin and formation of internal organs, must be exquisitely choreographed to ensure correct temporal ...
Dietary Restriction-Induced Longevity in Caenorhabditis elegans: Mediated by Stress Defense, NAD\(^+\)-Dependent Mechanisms and a Respiratory Shift
(2014-06-06)
Dietary restriction (DR), or the reduction of food consumption without malnutrition, is the most conserved method of preventing or reversing age associated diseases. It is also the most conserved method of increasing ...
Exploring the role of microRNAs in airway smooth muscle biology and asthma therapy
(2014-06-06)
The pathophysiology of asthma is characterized by airway inflammation, remodeling and hyper-responsiveness. Phenotypic changes in airway smooth muscle cells (ASM) play a pivotal role in the pathogenesis of asthma. ASM cells ...
Gene-Drug Interactions and the Evolution of Antibiotic Resistance
(2013-03-18)
The evolution of antibiotic resistance is shaped by interactions between genes, the chemical environment, and an antibiotic's mechanism of action. This thesis explores these interactions with experiments, theory, and ...
Genomic Approaches to Dissect Innate Immune Pathways
(2013-03-14)
The innate immune system is of central importance to the early containment of infection. When receptors of innate immunity recognize molecular patterns on pathogens, they initiate an immediate immune response by inducing ...
A ChIP-Mass Spectrometry Approach to Analysis of Dosage Compensation in Drosophila
(2013-03-11)
Dosage compensation is a process that many multicellular organisms employ to equalize the expression of X-linked genes between males and females. In Drosophila melanogaster, it is achieved by a two-fold transcriptional ...
A Role for PVRL4-Driven Cell-Cell Interactions in Tumorigenesis
(2013-03-18)
Deciphering genetic determinants of tumorigenesis is the greatest challenge and promise of the present-day era of biomedical research. As extensive tumor genome characterization efforts of the past decade had revealed, ...
Evolutionarily Conserved Function of Huntingtin in Cellular Dynamics Related to Cell Adhesion and the Cytoskeleton
(2013-03-15)
Huntington's disease (HD) is a rare, dominantly inherited neurodegenerative disorder characterized by progressive chorea, emotional and behavioral disturbances, and cognitive decline. The single, causative mutation is an ...