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Now showing items 41-50 of 618
Algorithms and Models for Genome Biology
(2014-02-25)
New advances in genomic technology make it possible to address some of the most fundamental questions in biology for the first time. They also highlight a need for new approaches to analyze and model massive amounts of ...
Design and synthesis of dynamically assembling DNA nanostructures
(2014-02-25)
Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed ...
Statistical Methods to Adjust for Measurement Error in Risk Prediction Models and Observational Studies
(2014-02-25)
The first part of this dissertation focuses on methods to adjust for measurement error in risk prediction models. In chapter one, we propose a nonparametric adjustment for measurement error in time to event data. Measurement ...
Functional organization of the circadian timing system
(2014-02-25)
The circadian timing system establishes daily rhythms in behavior and physiology throughout the body, ensuring that functions like activity, sleep and hormone release are appropriately timed. Research suggests that his ...
I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides
(2014-02-25)
Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ...
Cutaneous Biology and Endogenous Opioids: How the Skin Modulates Pain and Addiction
(2014-02-25)
The Proopiomelanocortin gene, (POMC), produces many biologically active peptides including the endogenous opioid, β-endorphin, and the melanocortins: α-Melanocyte Stimulating Hormone, (αMSH), γMSH, ...
Coherent scattering in two dimensions: graphene and quantum corrals
(2014-02-25)
Two dimensional electronic materials provide a vibrant area for applying basic quantum mechanics and scattering theory. In quantum corrals, multiple scattering leads to resonances closely approximating eigenstates of an ...
Novel Chemistries and Materials for Grid-Scale Energy Storage: Quinones and Halogen Catalysis
(2014-02-25)
In this work I describe various approaches to electrochemical energy storage at the grid-scale. Chapter 1 provides an introduction to energy storage and an overview of the history and development of flow batteries. Chapter ...
Dodging the Question: Language, Politics, and the Life of a Kenyan Literary Magazine
(2014-02-25)
This dissertation investigates the artistic and linguistic strategies employed by the Kenyan literary magazine Kwani? during a period of intense social and political upheaval. Between the peaceful end of Daniel Arap Moi's ...
Characterization of the Antibacterial Activity of the Type VI Secretion System
(2014-02-25)
This dissertation summarizes advances made toward understanding of the composition, structure, mechanism, and regulation of the bacterial type VI secretion system (T6SS). The T6SS is a widely conserved bacterial nanomachine ...