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Electronic Structure Predictions for Properties of Organic Materials
(2013-02-22)
Electronic structure calculations of organic molecules are an important set of tools to gain understanding of molecular structures. This thesis presents two separate contributions to applying quantum chemistry to organic ...
The Biochemistry and Physiology of Peptidases
(2013-03-14)
Peptidases regulate important physiological processes by controlling levels of bioactive peptides and occasionally through noncatalytic processes. This thesis presents a study of prolyl endopeptidase-like (PREPL), which ...
I. Completion of a Total Synthesis of Peloruside A. II. Studies toward the Total Synthesis of Spiro-Prorocentrimine
(2013-03-05)
I. Completion of a Total Synthesis of Peloruside A: The completion of a 22 step synthesis of the marine natural product peloruside A is presented. The second generation strategy cuts 10 steps from longest linear sequence ...
Multiplicative Expansion of the Pool of Fully Synthetic Tetracycline Antibiotics
(2013-03-05)
This thesis describes the development of chemical pathways for the preparation of more than 80 novel fully synthetic tetracyclines with structural variability at positions C5 and C5a. Progress toward the synthesis of ...
Late-Stage Fluorination with \(^{18}F\)
(2013-03-19)
Positron emission tomography (PET) is a powerful, non-invasive in vivo imaging technique used for diagnostics and drug development. The synthesis of \(^{18}F\)-PET tracers is challenging due to the short half-life of the ...
Nanowire Architectures for Next-Generation Solar Cells and Photonic Devices
(2013-02-15)
This thesis presents the design and synthesis of nanowires (NW) with targeted and tunable optical properties. Moreover, we show how single and assembled NW devices can enable new photovoltaic (PV) and photonic platforms. ...
Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome
(2013-02-19)
The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose ...
Sensing Inorganic Phosphate Starvation by the Phosphate-Responsive (PHO) Signaling Pathway of Saccharomyces cerevisiae
(2013-09-30)
Inorganic phosphate \((P_i)\) is an essential nutrient whose intracellular levels are maintained by the PHO pathway in Saccharomyces cerevisiae. \(P_i\) limitation triggers upregulation of the PHO genes whose gene products ...
Unconventional Strategies to Target Challenging Enzymes Using Small-Molecule Covalent Inhibitors
(2013-10-08)
Unconventional strategies employing covalent small molecules were investigated to down-regulate signaling pathways mediated by enzymes that are challenging to target. First, Her3 was selectively degraded using covalent ...
Dynamic Hybrid Materials: Hydrogel Actuators and Catalytic Microsystems
(2013-09-30)
Dynamic materials which can sense changes in their surroundings and subsequently respond or adapt by autonomously altering their functionality, surface chemistry, transparency, color, wetting behavior, adhesiveness, shape, ...