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On Sea Level - Ice Sheet Interactions
(2014-02-25)
This thesis focuses on the physics of static sea-level changes following variations in the distribution of grounded ice and the influence of these changes on the stability and dynamics of marine ice sheets. Gravitational, ...
Simulating personal future events: Contributions from episodic memory and beyond
(2014-02-25)
Episodic simulation refers to the construction of imagined, hypothetical events that might occur in one's personal future. Damage to our capacity for episodic simulation can produce grave consequences, impairing our ability ...
Global budget of black carbon aerosol and implications for climate forcing
(2014-02-25)
This thesis explores the factors controlling the distribution of black carbon (BC) in the atmosphere/troposphere and its implications for climate forcing. BC is of great climate interest because of its warming potential. ...
Residual Visions: Rubbish, Refuse and Marginalia in Italian Cinema from Neorealism to the Present
(2014-02-25)
While the themes of garbage and refuse pervade many of the most important works of Italian cinema from the era of Neorealism to the present, thus far no scholarly attempts have been made to examine the commonalities germane ...
A Bayesian Perspective on Factorial Experiments Using Potential Outcomes
(2014-02-25)
Factorial designs have been widely used in many scientific and industrial settings, where it is important to distinguish "active'' or real factorial effects from "inactive" or noise factorial effects used to estimate ...
HIV-1 capsid engages nucleoporin NUP153 to promote viral nuclear entry
(2014-02-25)
Lentiviruses can infect non-dividing cells, and various cellular nuclear transport proteins provide crucial functions for lentiviral nuclear entry and integration. Genome-wide small interfering RNA screens previously ...
Natural Law and the Law of Nature in Early British Beast Literature
(2014-02-25)
In the tumultuous political environment of late fifteenth- and early sixteenth-century Britain, animal literature saw rapid development and innovation. Beast fable and epic, which already had a long tradition in Latin and ...
TNF gene expression in macrophage activation and endotoxin tolerance
(2014-02-25)
TNF is an inflammatory cytokine that plays a critical role in the acute phase response to infection, and its dysregulation has been implicated in the pathology of several inflammatory and autoimmune disorders. TNF gene ...
Defining markers and mechanisms of human somatic cell reprogramming
(2014-02-25)
Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by over expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Using serial live cell immunofluorescence imaging of human fibroblasts ...
Trapping and Manipulating Single Molecules of DNA
(2014-02-25)
This thesis presents the development and application of nanoscale techniques to trap and