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Fitness Tradeoffs, Bimodality, and the Genetics of Natural Variation in Glucose-Galactose Sensing Across Saccharomyces Cerevisiae
(2017-01-26)
In nature, cells must constantly sense their environment and respond appropriately. These cellular “decisions” are implemented by molecular components that can mutate and evolve. How do mutations lead to changes in cellular ...
The Origin of Cell Fate Heterogeneity in Bacillus Subtilis
(2017-04-13)
A central question in biological development is how individual cells in a common environment are able to adopt distinct cell fates. In response to nutrient deprivation, Bacillus subtilis cells initiate the formation of a ...
Mechanisms of Bacterial Envelope Stress From Within and Without
(2017-01-25)
The bacterial cell envelope is the frontline protective barrier between the cell and the environment. It is a complex multilayered structure essential for maintaining cellular integrity and plays a crucial defensive role ...
The Role of MreB in Producing Rod-Shaped Bacterial Cells
(2017-09-08)
MreB, an actin homolog, is known to form short, membrane-associated filaments that move circumferentially in rod-shaped bacteria, in association with cell wall-synthesizing enzymes. Despite being essential for rod shape, ...
Biophysical Studies of the Lpt Pathway
(2017-07-06)
The outer membrane (OM) of Gram-negative bacteria is impermeable to many antibiotics because its outer leaflet is composed entirely of lipopolysaccharide (LPS), a large glycolipid with an extracellular saccharide that is ...
A Clock-Phased Sigma Factor Cascade Is Required for Global Circadian Transcriptional Rhythms in Cyanobacteria
(2017-09-07)
The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA transcript abundances with 24 h periodicity under continuous light conditions. The transcription factor RpaA ...
The Development of a Cell-Based Screen for Discovering Lipopolysaccharide Biogenesis Inhibitors
(2018-09-16)
Gram-negative bacteria are more difficult to kill than Gram-positive bacteria due to the presence of an outer membrane that prevents many antibiotics from reaching their cellular targets. The outer membrane is an asymmetric ...
Markov-Based Model of Cervicovaginal Bacterial Dynamics Predicts Community Equilibrium States in Young South African Women
(2018-06-29)
Commensal cervicovaginal bacteria modulate female genital tract (FGT) inflammation and HIV acquisition risk. High diversity communities with low Lactobacillus abundance are associated with more activated cervical HIV target ...
Intestinal Complement Modulates Colitis by Targeting the Gut Microbiota
(2018-01-22)
The proteins that make up the immune effector system known as complement are synthesized by hepatocytes and are present at high levels in the bloodstream. Serum complement not only displays antimicrobial activities such ...
Circadian Clocks in the Real World: Effects of Dynamic Light Regimes on the Regulation of Circadian Gene Expression in Cyanobacteria
(2017-09-13)
Organisms use internal oscillators to control their physiology in conjunction with the predictable environmental changes of the day/night cycle. However, it is not always clear how internal timing information is used by ...