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The Role of Dendritic Cell Subsets in Cross-presentation and Stimulation of Homing Marker Expression
(2014-02-25)
Topical antigen (Ag) application mimics natural Ag exposure across the skin. Soluble Ag introduced through this route requires cross-presentation by dendritic cells (DCs) to generate CD8 T cell responses, including skin-homing ...
HIV-1 capsid engages nucleoporin NUP153 to promote viral nuclear entry
(2014-02-25)
Lentiviruses can infect non-dividing cells, and various cellular nuclear transport proteins provide crucial functions for lentiviral nuclear entry and integration. Genome-wide small interfering RNA screens previously ...
Defining markers and mechanisms of human somatic cell reprogramming
(2014-02-25)
Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by over expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Using serial live cell immunofluorescence imaging of human fibroblasts ...
Secretory Mechanisms of aP2: an Adipokine Integrating Adipose Depots with Metabolism
(2014-06-06)
Adipose Fatty Acid Binding Protein 4 (FABP4) or aP2, plays an important role in several immunometabolic pathologies such as type 2 diabetes, atherosclerosis, fatty liver disease, asthma, and cancer. Long considered to be ...
Chemical Probes and the Exploration of Bromodomains in Cancer Biology
(2014-06-06)
The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate ...
Regulation of microRNA activity by translation initiation factors in melanoma
(2014-06-06)
microRNAs (miRNAs) are small, noncoding RNAs that may regulate more than half of human genes, yet the molecular mechanism of miRNA-mediated repression remains obscure. Using a cell-free assay of miRNA activity, we show ...
In search of breast cancer cell secretions with therapeutic and diagnostic value.
(2014-06-06)
The first end point of this study was to identify specific pro-apoptotic or anti-proliferative factors in the breast cancer cell secretome. To this end, we designed an in vitro screen that effectively cross-cultured 20 ...
Cellular and Biochemical Events in Toll-like Receptor Signaling
(2014-06-06)
In multicellular organisms, communication between cells relies on transmitting information across membrane barriers. Different cell types interrogate particular aspects of their surrounding environment through protein ...
The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
(2014-06-06)
Epithelial-mesenchymal transition (EMT) is a fundamental developmental program, which is believed to be reactivated during the progression of in situ carcinoma to aggressive metastatic cancers. Ras-ERK pathway has been ...
Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis
(2014-06-06)
Faced with an environment of constantly changing nutrient availability, mammals have adapted complex homeostatic mechanisms to maintain energy balance. Deviations from this balance are largely corrected through a concerted, ...