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The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
(2014-06-06)
Epithelial-mesenchymal transition (EMT) is a fundamental developmental program, which is believed to be reactivated during the progression of in situ carcinoma to aggressive metastatic cancers. Ras-ERK pathway has been ...
Reprogramming Pediatric Genetic Disorders: Pearson Syndrome, Ring 14 Syndrome, and Fanconi Anemia
(2014-06-06)
The effect of a single genetic mutation can vary greatly between different types of cells. The mutated gene may not be expressed in one tissue but may cause a devastating loss of function in another. To learn about disease ...
Chemical Probes and the Exploration of Bromodomains in Cancer Biology
(2014-06-06)
The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate ...
Dissecting Molecular Mechanisms of Shigella flexneri Cell-to-cell Spread
(2014-10-21)
Shigella is a causative agent of bacillary dysentery in humans. The ability of Shigella to disseminate in the intestinal epithelium is crucial for disease establishment. This process of cell-to-cell spread involves actin-based ...
Development of the CRISPR nuclease Cas9 for high precision mammalian genome engineering
(2014-10-21)
Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of genome function. Analogous to the search function in modern word ...
Modeling sporadic Alzheimer's disease using induced pluripotent stem cells
(2014-10-22)
Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation ...
Novel Roles for Ribonucleic Acids in Programmed Cell Death
(2014-10-22)
Apoptosis is a tightly coordinated program to shut down and dismantle a cell, characterized by mitochondrial outer membrane permeabilization (MOMP), caspase activation to cleave hundreds of proteins, DNA fragmentation, and ...
Filopodia-independent roles of the actin bundling protein fascin in promoting cell motility
(2014-10-22)
Fascin is an actin bundling protein whose overexpression has in recent years been systematically linked to increased metastasis and poor outcome in cancer patients. It is well established that fascin expression correlates ...
Development of Methods for Protein Delivery and the Directed Evolution of Recombinases
(2014-10-22)
As a class, protein-based therapeutics offer tremendous advantages over traditional small molecule drugs. Due to their sizes and folding energies, proteins are ideal for catalyzing chemical reactions, and can bind tightly ...
Exploring Cancer's Fractured Genomic Landscape: Searching for Cancer Drivers and Vulnerabilities in Somatic Copy Number Alterations
(2014-10-21)
Somatic copy number alterations (SCNAs) are a class of alterations that lead to deviations from diploidy in developing and established tumors. A feature that distinguishes SCNAs from other alterations is their genomic ...