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Adipose tissue FABP deficiency promotes metabolic reprogramming and positively impacts healthspan
(2014-02-25)
The adipose tissue lipid chaperones aP2 and mal1, also known as fatty acid binding proteins (FABPs), are significant molecules contributing to metabolic homeostasis, whereby their absence promotes physiological changes ...
Memory in a phenotypic switch and noise in gene networks
(2014-02-25)
Many cell types stochastically switch phenotypes under some conditions, so that genetically identical sister cells may behave quite differently in a common environment. This non-genetic variability likely arises from noise ...
Fluctuation Timescales in Bacterial Gene Expression
(2014-02-25)
The stochastic nature of intracellular chemistry guarantees that even genetically identical cells sharing an environment will differ in composition. The question of whether this chemical diversity translates into significant ...
Characterization of the Antibacterial Activity of the Type VI Secretion System
(2014-02-25)
This dissertation summarizes advances made toward understanding of the composition, structure, mechanism, and regulation of the bacterial type VI secretion system (T6SS). The T6SS is a widely conserved bacterial nanomachine ...
HIV-1 capsid engages nucleoporin NUP153 to promote viral nuclear entry
(2014-02-25)
Lentiviruses can infect non-dividing cells, and various cellular nuclear transport proteins provide crucial functions for lentiviral nuclear entry and integration. Genome-wide small interfering RNA screens previously ...
TNF gene expression in macrophage activation and endotoxin tolerance
(2014-02-25)
TNF is an inflammatory cytokine that plays a critical role in the acute phase response to infection, and its dysregulation has been implicated in the pathology of several inflammatory and autoimmune disorders. TNF gene ...
Secretory Mechanisms of aP2: an Adipokine Integrating Adipose Depots with Metabolism
(2014-06-06)
Adipose Fatty Acid Binding Protein 4 (FABP4) or aP2, plays an important role in several immunometabolic pathologies such as type 2 diabetes, atherosclerosis, fatty liver disease, asthma, and cancer. Long considered to be ...
Tracking Cell Fate with Synthetic Memory and Pulse Detecting Transcriptional Circuits
(2014-06-06)
Synthetic biology aims to engineer biological systems to meet new challenges and teach us more about natural biological systems. These pursuits range from the building of relatively simple transcriptional circuits, to ...
Genome Engineering Technology and Its Application in Mammalian Cells
(2014-06-06)
The advancement of high-throughput, large-scale biochemical, biophysical, and genetic technologies has enabled the generation of massive amounts of biological data and allowed us to synthesize various types of biomaterial ...
Genome-wide Analysis of Ctcf-RNA Interactions
(2014-06-06)
Ctcf is a "master regulator" of the genome that plays a role in a variety of gene regulatory functions as well as in genome architecture. Evidence from studying the epigenetic process of X-chromosome inactivation suggests ...