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The Roles of RNA-binding Proteins in the Developing Nervous System
(2014-02-25)
RNA-binding proteins are key players in post-transcriptional regulation of gene expression by orchestrating RNA fate from synthesis to decay. Hundreds of proteins with RNA-binding capacity have been identified so far, yet ...
Cutaneous Biology and Endogenous Opioids: How the Skin Modulates Pain and Addiction
(2014-02-25)
The Proopiomelanocortin gene, (POMC), produces many biologically active peptides including the endogenous opioid, β-endorphin, and the melanocortins: α-Melanocyte Stimulating Hormone, (αMSH), γMSH, ...
Simulating personal future events: Contributions from episodic memory and beyond
(2014-02-25)
Episodic simulation refers to the construction of imagined, hypothetical events that might occur in one's personal future. Damage to our capacity for episodic simulation can produce grave consequences, impairing our ability ...
High-level neural structures constrain visual behavior
(2014-06-06)
Visual cognition is notoriously limited: only a finite amount of information can be fully processed at a given instant. What is the source of these limitations? Here, we suggest that the organization of higher-level visual ...
Dissecting Olfactory Circuits in Drosophila
(2014-06-06)
Drosophila is a simple and genetically tractable model system for studying neural circuits. This dissertation consists of two studies, with the broad goal of understanding sensory processing in neural circuits using ...
Regeneration in the aging peripheral nervous system
(2014-06-06)
In the peripheral nervous system (PNS), aging is associated with a number of disorders, including a decline in regenerative capacity after injury. Although this decline has been observed in both rodents and humans for ...
TRPV1 Sensitization in Primary Sensory Neurons
(2014-06-06)
Pain is a major personal and community burden throughout the world with currently limited treatment options for persistent pain due to unacceptable side effects, dependence or frank inefficacy. It is necessary to understand ...
The role of motor cortex in the acquisition and production of learned motor sequences
(2014-06-06)
Motor skill learning underlies much of what we do, be it hitting a tennis serve, playing the piano, or simply brushing our teeth. Yet despite its importance, little is known about the neural circuits that implement the ...
Social Behavior and Gene Expression Disturbances in Mouse Models of Angelman Syndrome and Idic15 Autism
(2014-06-06)
Reciprocal changes in UBE3A gene dosage cause two neurodevelopmental disorders. Maternally inherited deletions of UBE3A cause Angelman syndrome, characterized by intellectual disability, motor defects, seizures, and a ...
Blind to Their Blindness: A History of the Denial of Illness
(2014-06-06)
For many historians, sociologists, and anthropologists of medicine, "disease" and "illness" are not equivalent. Whereas "disease" denotes the physician's ostensibly objective criteria, "illness" emphasizes the patient's ...