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Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
(2018-04-19)
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...
Catalytic, Stereoselective Fluorination Reactions
(2018-12-03)
In Chapter 1, we describe a general strategy for 1,3-oxidation of cyclopropanes using aryl iodine(I–III) catalysis, with emphasis on 1,3-difluorination reactions. These reactions make use of practical, commercially available ...
Regulation of the Mitochondrial Calcium Uniporter by the MICU1/MICU2 Complex: From Biochemistry to Human Disease
(2018-04-30)
The mitochondrial calcium uniporter is an evolutionarily ancient calcium channel, with purported roles in many areas of cellular and organismal physiology from excitation: energetic coupling to cell death. The molecular ...
Mechanistic Studies of First-Row Metal-Mediated and -Catalyzed Reactions
(2018-04-10)
First-row transition metals find growing applications in organic transformations due to their abundance and low cost. In addition, the difference in redox states of first-row metals to those of second or third row metals ...
Development of Small Molecule Kinase Degraders as Chemical Biology Probes and Cancer Therapies
(2018-09-20)
Advances in chemical biology provide immense benefits to human health through the discovery of new medicines and new scientific tools to study disease. I have contributed to the advancement of this field by developing a ...
Synthesis and rapid biological annotation of single-enantiomer small molecules
(2018-09-17)
Small molecules play key roles in biological processes and have been suggested to be the “missing link” in the central dogma of molecular biology. Discovery campaigns facilitated by the high-throughput screening of millions ...
Towards Constructing Informational Replicating Systems in Nonenzymatic Environments
(2018-09-16)
Tremendous efforts have been made in building an artificial protocell that could undergo self-replication and Darwinian evolution. Self-replicating genetic polymers, which serve as major components of protocells, have been ...
Novel Lincosamide Antibiotics Containing an Azepane Amino Acid Moiety
(2018-12-03)
Clindamycin is the only member of the lincosamide class of antibiotics currently used in the clinic. It is used to treat Gram-positive infections, including infections caused by methicillin-resistant S. aureus (MRSA). ...
Development of Organic Molecules for Aqueous Redox Flow Battery
(2018-05-02)
The cost of renewable energy sources such as solar and wind has dropped significantly such that the main barrier for a wider adoption is intermittency. The unsynchronized power supply from renewables and the power demand ...
Elucidating Heterogeneous Mixed-Metal Synergy Through Electrochemical and Electronic Studies of Earth-Abundant Oxygen Evolving Catalysts
(2018-08-08)
Solar power is a promising contender to replace fossil fuels with its inexhaustible supply and relatively low cost. Energy storage remains the missing link between intermittent solar supply and on-demand energy output. ...