Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...

In Chapter 1, we describe a general strategy for 1,3-oxidation of cyclopropanes using aryl iodine(I–III) catalysis, with emphasis on 1,3-difluorination reactions. These reactions make use of practical, commercially available ...

The mitochondrial calcium uniporter is an evolutionarily ancient calcium channel, with purported roles in many areas of cellular and organismal physiology from excitation: energetic coupling to cell death. The molecular ...

First-row transition metals find growing applications in organic transformations due to their abundance and low cost. In addition, the difference in redox states of first-row metals to those of second or third row metals ...

Advances in chemical biology provide immense benefits to human health through the discovery of new medicines and new scientific tools to study disease. I have contributed to the advancement of this field by developing a ...

Small molecules play key roles in biological processes and have been suggested to be the “missing link” in the central dogma of molecular biology. Discovery campaigns facilitated by the high-throughput screening of millions ...

Tremendous efforts have been made in building an artificial protocell that could undergo self-replication and Darwinian evolution. Self-replicating genetic polymers, which serve as major components of protocells, have been ...

Clindamycin is the only member of the lincosamide class of antibiotics currently used in the clinic. It is used to treat Gram-positive infections, including infections caused by methicillin-resistant S. aureus (MRSA). ...

The cost of renewable energy sources such as solar and wind has dropped significantly such that the main barrier for a wider adoption is intermittency. The unsynchronized power supply from renewables and the power demand ...

Solar power is a promising contender to replace fossil fuels with its inexhaustible supply and relatively low cost. Energy storage remains the missing link between intermittent solar supply and on-demand energy output. ...