Transcriptional regulation is a key determinant of cell differentiation during development. Changes in where and when a gene is expressed can lead to phenotypic variation among individuals, and ultimately to phenotypic ...

Transcriptional control is critical to the proper functioning of cells, their growth, differentiation, and survival. Because genomic and epigenomic alterations can deregulate transcription and promote an oncogenic state, ...

The cycle of day and night is among the most recurrent and predictable environmental changes. In order to thrive, organisms across all domains of life evolved regulatory strategies to respond to diurnal fluctuations in ...

Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...

All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...

Nanopores can be used as extremely sensitive instruments to directly measure properties of individual molecules. Progress in the nanopore field has been motivated largely by a desire to sequence DNA quickly and accurately. ...

Nanodiscs have been an excellent tool for encouraging biochemists and structural biologists to study membrane proteins. They are composed of a discoidal lipid bilayer and two copies of a membrane scaffold protein (MSP). ...

Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...

We currently understand very little about how the genome functions. Up to 80% of the genome is transcribed, but much of biology focuses on the ~1-5% that codes for proteins. This narrow focus leaves many newly cataloged ...

The importance of oncogenic KRAS in human cancers have prompted intense efforts to target KRAS and its effectors. To anticipate the development of resistance to these strategies, we previously performed a genome-scale ...