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Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis
(2018-04-10)
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
Glycomic regulation of human B cells
(2018-09-16)
All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...
Investigation of KRAS Dependency Bypass and Functional Characterization of All Possible KRAS Missense Variants
(2018-05-11)
The importance of oncogenic KRAS in human cancers have prompted intense efforts to target KRAS and its effectors. To anticipate the development of resistance to these strategies, we previously performed a genome-scale ...
The Design and Characterization of Bifunctional Degraders of TRIM24, a Novel Transcriptional Dependency in Hematologic Malignancies
(2018-04-24)
Transcriptional control is critical to the proper functioning of cells, their growth, differentiation, and survival. Because genomic and epigenomic alterations can deregulate transcription and promote an oncogenic state, ...
Directed evolution of Cas9 for mammalian genome editing
(2018-05-14)
The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...
Activation and Antagonism of RIG-I-Mediated Innate Immune Signaling by Herpes Simplex Virus 1
(2018-01-16)
The cytosolic innate immune receptor retinoic acid-inducible gene-I (RIG-I) recognizes double-stranded RNA (dsRNA) that emerges during viral infection and initiates an antiviral response comprised of interferon (IFN) and ...
Causality in Epigenetics: Strategies for Targeted Epigenome Engineering of Transcriptional Regulation and Genome Topology
(2018-05-14)
Changes in epigenetic states are at the heart of normal developmental processes and also underlie many human diseases. Studies to date have established strong associations between histone post-translational modifications, ...
Functional analysis of multiple activities associated with the herpes simplex virus-1 DNA polymerase
(2018-05-11)
Of the DNA replication proteins required for herpes simplex virus-1 (HSV-1) viral replication, the catalytic subunit of the DNA polymerase (Pol) has been the most extensively studied, both as a model for Family B polymerases ...