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Envelope biogenesis and spore formation in Bacillus subtilis
The bacterial cell wall exoskeleton (or peptidoglycan) protects cells from osmotic lysis, specifies their shape, and its biosynthetic pathway is a widely-exploited antibiotic target. My thesis research focused on defining ...
Identification of MltG as a Potential Terminase for Peptidoglycan Polymerization in Bacteria
Bacterial cells are fortified against osmotic lysis by a cell wall made of peptidoglycan (PG). Synthases called penicillin-binding proteins (PBPs), the targets of penicillin and related antibiotics, polymerize the glycan ...
Mechanisms Controlling the Cell Envelope Remodeling Activities of the Escherichia Coli Cytokinetic Ring
In Escherichia coli, cytokinesis requires the constriction of all the cell envelope layers: the inner membrane, the peptidoglycan (PG) cell wall and the outer membrane (OM). Such dramatic cell envelope remodeling requires ...
The role of integrins and human IDO in the immune response to Chlamydia trachomatis
Chlamydia trachomatis is the most common sexually transmitted bacterial infection in the United States. Genital C. trachomatis infections cause serious morbidity, including pelvic inflammatory disease and infertility. ...
A genetic dissection of the interactions between the CbtA toxin of Escherichia coli and the bacterial cytoskeleton
Prokaryotic chromosomal toxin-antitoxin (TA) systems, consisting of a stable toxin and a labile, cotranscribed antitoxin, have been shown to target a number of essential processes in bacteria. The Escherichia coli genome ...