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Biology of Type 2 Phosphatidylinositol-5-Phosphate 4-Kinase
(2015-09-22)
Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes ...
Diverse Approaches to Developing Combination Therapies for NF1-Mutant Cancers
(2015-05-13)
The NF1 tumor suppressor is lost or mutated in a variety of sporadic cancers, as well as in the hereditary cancer predisposition syndrome neurofibromatosis type 1 (NF1). NF1 patients have an 8–13% risk of developing a ...
Genome evolution in structured systems
(2016-05-14)
The evolution of a genome is shaped by spatial interactions at multiple scales. At the angstrom level, structural constraints on both RNA molecules and proteins contribute to the evolution of a gene sequence. Such optimized ...
Strategies for Studying Chromatin Regulation and Organization
(2016-04-22)
The epigenetic regulation of gene transcription underlies the diversity between species and within organisms. Novel implementation of existing methods and the development of original technologies continue to contribute ...
Molecular Patterns and Signatures of Longevity
(2016-05-02)
Since their divergence from a common ancestor some 200 million years ago, mammals have undergone significant diversification in physiology, morphology, habitat, size, and longevity. The maximum lifespan of mammalian species ...
Genetic and genomic approaches to understand size and proportion
(2017-01-10)
The establishment of proper proportions during development is essential for the final form and function of an organism. While much is known concerning the regulation of proliferation and differentiation, how the relative ...
Genetic and Molecular Dissection of the Integration of Galactose and Glucose Signaling in Saccharomyces Cerevisiae Strains
(2015-05-21)
Cells need to sense the environment in order to survive, in particular they need to detect nutrients which will provide different building blocks and energy for the cell. This task is complicated by the fact that there can ...
Genetic Engineering Toward a 57-Codon Genome
(2017-01-09)
Scientific progress in fundamental biology has drastically transformed our ability to engineer biological systems, with diverse applications in medicine and industry, from insulin and artemisin production in prokaryotes ...
Directed evolution of Cas9 for mammalian genome editing
(2018-05-14)
The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...
Experimental Evolution of Cellular Response Networks in Yeast
(2017-05-10)
Organisms respond to environmental changes using complex signaling networks, whose evolution has been studied by comparing their structure and function in related organisms. We complemented this approach by using experimental ...