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On Clocks and Tuners: Cyanobacterial Strategies to Thrive in a Dynamic Environment
(2018-01-05)
The cycle of day and night is among the most recurrent and predictable environmental changes. In order to thrive, organisms across all domains of life evolved regulatory strategies to respond to diurnal fluctuations in ...
High-Throughput Genetic Analysis of Single Cells Using Microfluidically Generated Hydrogels
(2018-01-22)
Typical metagenomic datasets characterize populations as a whole by sequencing all the DNA fragments present in a sample, and are therefore unable to identify different genes as having originated from the same cell or ...
Global post-transcriptional regulators in Pseudomonas aeruginosa
(2018-08-17)
Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen found ubiquitously in both natural and manmade environments. Central to its ability to grow in different environments is the organism’s coordinated ...
The Development of a Cell-Based Screen for Discovering Lipopolysaccharide Biogenesis Inhibitors
(2018-09-16)
Gram-negative bacteria are more difficult to kill than Gram-positive bacteria due to the presence of an outer membrane that prevents many antibiotics from reaching their cellular targets. The outer membrane is an asymmetric ...
Markov-Based Model of Cervicovaginal Bacterial Dynamics Predicts Community Equilibrium States in Young South African Women
(2018-06-29)
Commensal cervicovaginal bacteria modulate female genital tract (FGT) inflammation and HIV acquisition risk. High diversity communities with low Lactobacillus abundance are associated with more activated cervical HIV target ...
Intestinal Complement Modulates Colitis by Targeting the Gut Microbiota
(2018-01-22)
The proteins that make up the immune effector system known as complement are synthesized by hepatocytes and are present at high levels in the bloodstream. Serum complement not only displays antimicrobial activities such ...
Peptidoglycan Synthesis and Rod Shape Maintenance in Mycobacteria
(2018-04-25)
Bacteria surround themselves with a cell wall whose foundation is a layer called peptidoglycan. Peptidoglycan is a mesh of linear glycan strands that are linked together by short peptide side chains. As a crucial bacterial ...
Gut and Tissue Microbiome Biogeography and Its Response to Environmental Perturbation
(2018-01-18)
The symbiotic relationship between the host and its microbiome, which is composed of trillions of bacteria, archaea, viruses, and fungi, is essential for the host to maintain health. In the past two decades, the intestinal ...
Engineering Bacteria for Bio-Based Chemicals Production and Gut Microbiota Applications
(2018-09-16)
Microbes have been used for production of food and beverages for thousands of years. In the last century we have begun to modify them by means of genetic engineering to produce more complex compounds and we have gained ...
Phage Assisted Evolutions for Engineering Biosynthetic Pathways
(2018-05-14)
Phage Assisted Continuous Evolution (PACE) and its derivative techniques are powerful tools for evolving improved and altered enzymatic activities. Prior to this work, no one had demonstrated the applicability of these ...