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Markov Chain Monte Carlo Sampling Algorithms in Neural Circuitry
(2022-06-03)
There is growing evidence that the nervous system is tuned and adapted to the sta- tistical properties of the sensory information from the surrounding environment and that it is possible that the brain performs some form ...
Optical investigation of microcircuit computations in mouse primary visual cortex
(2022-01-20)
A fundamental challenge of visual cortical neuroscience is to understand how sensory representations are transformed within and across layers of primary visual cortex (V1). Visual signals are thought to propagate in a ...
Towards an Artificial Visual System More Like the Primate Visual System
(2022-09-12)
Current state-of-the-art object recognition models in computer vision are largely based on convolutional neural network (CNN) architectures, which are loosely inspired by the primate visual system. While many of these same ...
Define the RelationSHIP: INPP5D/SHIP1 regulates inflammasome activation in human microglia
(2022-09-09)
Microglia and neuroinflammation are implicated in the development and progression of Alzheimer’s disease (AD). However, there are limitations to studying human microglia and utilizing mouse models to study microglia function. ...
Distinct forms of spinal cord inhibition regulate tactile reactivity in mouse models of autism spectrum disorders
(2022-05-04)
Individuals with autism spectrum disorders (ASDs) frequently report altered reactivity to sensory stimuli, with many individuals displaying over-responsivity to tactile stimuli. Genetic factors explain much of the risk for ...
Uncertainty and learning in a biological ring attractor
(2022-09-15)
Navigation often occurs under uncertain conditions, where spatial information
is incomplete. In this thesis project, we set out to study how uncertainty affects
the head direction (HD) system in the Drosophila brain, a ...
Ramping activity in the medial prefrontal cortex integrates time and rewards in opposing directions during patch foraging
(2022-03-17)
As animals forage for food and water, a key decision they need to make is when to abandon a depleting resource to search elsewhere in the environment. The Marginal Value Theorem (MVT) provides a normative framework for ...
Biologically-Inspired Deep Predictive Learning for Episodic Memory Event Segmentation
(2022-05-23)
Computational modeling for event segmentation in the literature has been directed
towards detailing individual regions of the brain, mainly the hippocampus, prefrontal cortex and
substantia nigra and the role they play in ...
Highly Selective Brain-To-Gut Communication via Genetically Defined Vagus Neurons
(2022-03-17)
The dorsal motor nucleus of the vagus (DMV) is the primary source of parasympathetic input to the digestive system and innervates many digestive organs. However, its organizational principles are poorly understood and it’s ...
The Nature and Origins of Selectivity for Music in the Human Brain
(2022-01-04)
Music is uniquely and universally human, and arises early in development. Recent fMRI studies have revealed neural populations in non-primary auditory cortex that respond selectively to music, responding strongly to a wide ...