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Investigating Cytoskeletal Motor Mechanisms using DNA Nanotechnology
(2014-02-25)
The microtubule cytoskeleton plays a vital role in the spatial-temporal organization of subcellular cargo required to maintain homeostasis and direct cell division. Cytoplasmic dynein and kinesin are opposite-polarity, ...
Trapping and Manipulating Single Molecules of DNA
(2014-02-25)
This thesis presents the development and application of nanoscale techniques to trap and
Biology at single-molecule and single-cell level: chromosome organization, gene expression and beyond
(2014-06-06)
Single molecules and single cells are the fundamental building blocks in biology. Facilitated by the advancement of technology, quantitative single-molecule and single-cell measurements provide a unique perspective toward ...
Mechanism of endoplasmic reticulum membrane fusion mediated by the Atlastin GTPase
(2014-10-21)
How organelles acquire their unique shapes is a fundamental question of cell biology. The peripheral endoplasmic reticulum (ER) consists of a vast network of membrane sheets and tubules, the formation of which requires ...